Project Portfolio

Project Portfolio

Topical analgesic gel for anorectal pain relief

A topical gel to relief anorectal post-surgery pain and inflammation.

An effective balm in the treatment of pain and inflammation for common anorectal afflictions.

Problema per ser solucionat 
Management of postoperative anorectal pain and discomfort is suboptimal world-wide. In addition, anorectal disorders are a prevalent condition in a high percentage of adult and elder people. A new product to relief this kind of pain and inflamation would be highly valuable.
Aplicacions 

This topical gel can be used in pre and post anorectal surgery (such as hemorrhoids, anal fistula and anal fissure, among others) patients to relief local pain. It can also be used to treat pain in anorectal persisting disorders.

Estat de tecnologia 
The gel has been formulated and produced by galenic development experts and it has already been successfully tested in patients in a pilot study. It has been proven experimentally in patients after benign anorectal surgery with 120 patients obtaining excellent results in a clinical trial approved by the Spanish Agency of Drugs. IP status: A European patent application has been filled and the PCT submission has been requested.
Oportunitat de mercat 
Anorectal disorders are commonly encountered in general surgical practice and as a chronic disease. These disorders are common, worldwide and their prevalence in the general population is probably much higher than that seen in clinical practice as most patients do not seek medical attention. Patients with diseases of the anus and rectum are usually in pain, often anxious and frequently embarrassed by the examination. 3.25 million units of antihemorroïdals were sold in the last 12 months (period from October 12 - to September 13) only in the Spanish market, with a value of 17.2 M € (in PVL value). The topical treatment proposed for anorectal pain is new, unique and directed to a necessary field of application with strong market demand. This is an effective gel for pain treatment which will lead to patient satisfaction, lower medical costs and shorter hospital stays.
Context 
Anorectal disorders are widespread condition affecting the general population with a prevalence of 40% in adults and 100% occasionally in elder people over 65 years old. Rectal surgery includes hemorrhoids, anal fistula and anal fissure, having hemorrhoids a prevalence rate of 4.4% among all population. Hemorrhoids are an extremely common condition, affecting approximately 10 million persons per year. One study estimated that more than 50% of the US population over age 50 years has experienced hemorrhoids. Postoperative pain is handled in such many different ways that none of them is purely effective. There is no topical alternative for the treatment of postoperative pain in anorectal benign surgery due to medical contraindications of existing products. Current pain solutions proposed require use of burdensome devices and are uncomfortable for the patients.
Tecnologia 
This is a new semi-solid pharmaceutical drug for topical rectal administration in the treatment of pre and post-operative period in benign anorectal surgery. Most existing topical formulations contain corticoid, contraindicated in surgical wounds. With this innovation, pain is managed in a comprehensive manner, thanks to the combination of a local anesthetic and a nonsteroidal anti-inflammatory. The use of topical gel allows putting aside analgesic current technologies that are more complex and iatrogenic such as analgesia administration by epidural PCA pumps, that prolong hospital stay, or subcutaneously elastomeric pumps at home, unpleasant for the patient and requiring training for its use. It is composed by two known active substances, but never combined before for this indication, in a safe, effective, stable and quality formula.
Technology Readiness Level 
TRL 6
Què busquem? 
Acord de llicència
Inventors 
Linares Ma (IDIBELL, HV)
Patent No. 
EP15382416.4
Priority Date 
08/05/2015

Topical analgesic gel for anorectal pain relief

Technology Readiness Level 
Què busquem? 
Acord de llicència
Patent No. 
EP15382416.4
Priority Date 
08/05/2015
Punts destacats 
A topical gel to relief anorectal post-surgery pain and inflammation.An effective balm in the treatment of pain and inflammation for common anorectal afflictions.
Problema per ser solucionat 
Management of postoperative anorectal pain and discomfort is suboptimal world-wide. In addition, anorectal disorders are a prevalent condition in a high percentage of adult and elder people. A new product to relief this kind of pain and inflamation would be highly valuable.
Aplicacions 

This topical gel can be used in pre and post anorectal surgery (such as hemorrhoids, anal fistula and anal fissure, among others) patients to relief local pain. It can also be used to treat pain in anorectal persisting disorders.

Estat de tecnologia 
The gel has been formulated and produced by galenic development experts and it has already been successfully tested in patients in a pilot study. It has been proven experimentally in patients after benign anorectal surgery with 120 patients obtaining excellent results in a clinical trial approved by the Spanish Agency of Drugs. IP status: A European patent application has been filled and the PCT submission has been requested.
Oportunitat de mercat 
Anorectal disorders are commonly encountered in general surgical practice and as a chronic disease. These disorders are common, worldwide and their prevalence in the general population is probably much higher than that seen in clinical practice as most patients do not seek medical attention. Patients with diseases of the anus and rectum are usually in pain, often anxious and frequently embarrassed by the examination. 3.25 million units of antihemorroïdals were sold in the last 12 months (period from October 12 - to September 13) only in the Spanish market, with a value of 17.2 M € (in PVL value). The topical treatment proposed for anorectal pain is new, unique and directed to a necessary field of application with strong market demand. This is an effective gel for pain treatment which will lead to patient satisfaction, lower medical costs and shorter hospital stays.
Context 
Anorectal disorders are widespread condition affecting the general population with a prevalence of 40% in adults and 100% occasionally in elder people over 65 years old. Rectal surgery includes hemorrhoids, anal fistula and anal fissure, having hemorrhoids a prevalence rate of 4.4% among all population. Hemorrhoids are an extremely common condition, affecting approximately 10 million persons per year. One study estimated that more than 50% of the US population over age 50 years has experienced hemorrhoids. Postoperative pain is handled in such many different ways that none of them is purely effective. There is no topical alternative for the treatment of postoperative pain in anorectal benign surgery due to medical contraindications of existing products. Current pain solutions proposed require use of burdensome devices and are uncomfortable for the patients.
Tecnologia 
This is a new semi-solid pharmaceutical drug for topical rectal administration in the treatment of pre and post-operative period in benign anorectal surgery. Most existing topical formulations contain corticoid, contraindicated in surgical wounds. With this innovation, pain is managed in a comprehensive manner, thanks to the combination of a local anesthetic and a nonsteroidal anti-inflammatory. The use of topical gel allows putting aside analgesic current technologies that are more complex and iatrogenic such as analgesia administration by epidural PCA pumps, that prolong hospital stay, or subcutaneously elastomeric pumps at home, unpleasant for the patient and requiring training for its use. It is composed by two known active substances, but never combined before for this indication, in a safe, effective, stable and quality formula.