• Identification and characterisation of new immunomodulator proteins and evaluation of their relevance and therapeutic potential in autoimmune processes and organ transplantation.
  • Analysis of new diagnostic/prognostic biomarkers in acute and chronic inflammatory pathologies.
  • Oxidative stress in epithelial cells of the respiratory pathways. Inflammatory molecular mechanisms.

Complement components as promoters of immunological tolerance in dendritic cells

Luque A., Serrano I., Aran J.

SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY (ISSN/ISBN: 10849521)

2019

Exploring the Immunomodulatory Moonlighting Activities of Acute Phase Proteins for Tolerogenic Dendritic Cell Generation

Serrano, Inmaculada; Luque, Ana; Aran, Josep M.;

FRONTIERS IN IMMUNOLOGY (ISSN/ISBN: 16643224). 9 : ARTN 892

2018

Association between low levels of serum miR-638 and atherosclerotic plaque vulnerability in patients with high-grade carotid stenosis.

Luque A, Farwati A, Krupinski J, Aran JM

JOURNAL OF NEUROSURGERY. (ISSN/ISBN: 00223085). 1-8

2018

The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells

Olivar R, Luque A, Cárdenas-Brito S, Naranjo-Gómez M, Blom AM, Borràs FE, Rodriguez de Córdoba S, Zipfel PF, Aran JM

JOURNAL OF IMMUNOLOGY (ISSN/ISBN: 00221767)4290

2016

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

Vento-Tormo, Roser; Company, Carlos; Rodriguez-Ubreva, Javier; de la Rica, Lorenzo; Urquiza, Jose M.; Javierre, Biola M.; Sabarinathan, Radhakrishnan; Luque, Ana; Esteller, Manel; Aran, Josep M.; Alvarez-Errico, Damiana; Ballestar, Esteban;

GENOME BIOLOGY (ISSN/ISBN: 1474760X). 17 (1)

2016

Low levels of serum miR-638 are associated with atherosclerotic plaque vulnerability in patients with high-grade carotid stenosis

Aran Perramon, Jose Maria

STROKE: A JOURNAL OF CEREBRAL CIRCULATION. (ISSN/ISBN: 00392499). SUBMITTED

2016

CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury

de Ramon, Laura; Ripoll, Ella; Merino, Ana; Lucia, Marc; Aran, Josep M.; Perez-Rentero, S.; Lloberas, Nuria; Cruzado, Josep M.; Grinyo, Josep M.; Torras, Juan;

KIDNEY INTERNATIONAL (ISSN/ISBN: 00852538). 88 (3) : 538-549

2015

Human mesenchymal stem cells resolve airway inflammation, hyperreactivity and histopathology in a mouse model of occupational asthma.

Martínez-González I., Cruz M., Moreno R., Morell F., Muñoz X., Aran J.

STEM CELLS AND DEVELOPMENT. (ISSN/ISBN: 15473287). 23(19): 2352-2363

2014

Human Mesenchymal Stem Cells Resolve Airway Inflammation, Hyperreactivity, and Histopathology in a Mouse Model of Occupational Asthma

Martinez-Gonzalez, Itziar; Cruz, Maria-Jesus; Moreno, Rafael; Morell, Ferran; Munoz, Xavier; Aran, Josep M.;

STEM CELLS AND DEVELOPMENT (ISSN/ISBN: 15473287). 23 (19) : 2352-2363

2014

Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy

Luque, Ana; Farwati, Abduljalil; Crovetto, Francesca; Crispi, Fatima; Figueras, Francesc; Gratacos, Eduard; Aran, Josep M

SCIENTIFIC REPORTS (ISSN/ISBN: 20452322). 4 : 4882-4882

2014

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INMUNOMODULACION MEDIADA POR INHIBIDORES SOLUBLES DEL COMPLEMENTO: IMPLICACIONES DIAGNÓSTICAS Y TERAPÉUTICAS EN AUTOINMUNIDAD.

Aran Perramon, Jose Maria (Investigador principal (IP))

Ref.: PI16/00377

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2017-01-01 - 2019-12-31

Kit per al diagnòstic / pronòstic d'ictus isquèmic en individus amb estenosi carotídia elevada

Aran Perramon, Jose Maria (Investigador principal (IP))

Ref.: 2016-01-004

Entitat finançadora:
  • FUND.INST.CENTRES RECER.CATALALUYA

2016-01-01 - 2017-12-31

ENGINERED STEM CELLS AND THEIR THERAPEUTIC USE

Aran Perramon, Jose Maria (Investigador principal (IP))

Ref.: EP11382362

Entitat finançadora:
  • HISTOCELL, S.L.

2014-06-01 - 2017-09-12

COMPOSITIONS AND METHODS FOR IMMUNOMODULATION

Aran Perramon, Jose Maria (Investigador principal (IP))

Ref.: EP11382240

NUEVA ACTIVIDAD ANTI-INFLAMATORIA E INMUNOMODULADORA DE C4BP Y FACTOR H: POTENCIAL DIAGNÓSTICO Y TERAPÉUTICO EN PROCESOS INMUNO-INFLAMATORIOS

Aran Perramon, Jose Maria (Investigador principal (IP))

Ref.: PI13/01490

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2014-01-01 - 2017-09-30

Nueva actividad anti-inflamatoria e inmunomoduladora de C4BP y Factor H: potencial diagnóstico y terapéutico en los procesos inmuno-inflamatorios.

Luque Gomez, Ana (Participante)

Novel anti-inflammatory and immunomodulatory activity of C4BP and Factor H: diagnostic and therapeutic potential in immune-inflammatory processes. Entidad de

Checa Raya, Javier (Participante)

Ref.: ExpPI13/01490

Entitat finançadora:
  • INSTITUTO DE SALUD CARLOS III

2014-01-01 - 2016-01-01

Novel anti-inflammatory and immunomodulatory activity of C4BP and Factor H: diagnostic and therapeutic potential in immune-inflammatory processes

Aran Perramon, Jose Maria (Participante)

2014-01-01 - 2016-01-01

Capacitat immunomoduladora i antiinflamatòria de la isoforma reguladora del complement C4BP(b-): cap a la prevenció de la pèrdua de l’empelt en trasplantament d’òrgans

Luque Gomez, Ana (Participante)

Entitat finançadora:
  • FUNDACIÓ LA MARATÓ DE TV3

CONTRATOS DE APOYO A LA INVESTIGACION EN EL SISTEMA NACIONAL DE SALUD

Garcia Vilanova, Andreu (Investigador principal (IP))

Ref.: CA12/00247

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2013-01-01 - 2015-12-31

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Actividad anti-inflamatoria e inmunomoduladora de los inhibidores solubles del complemento C4BP β– y factor H

Nunes Martinez, Virginia (Director) Doctorando: Sonia Janneth Cardenas Brito; Aran Perramon, Jose Maria (Director) Doctorando: Sonia Janneth Cardenas Brito

2016

Nuevas estrategias terapéuticas anti-inflamatorias y regenerativas en modelos de patología pulmonar

Aran Perramon, Jose Maria (Director) Doctorando: Itziar Martínez González

2012

Novel anti-inflammatory and regenerative therapeutic strategies in animal models of lung injury

Aran Perramon, Jose Maria (Director)

2012

Contribution of circulating sCD40L and soluble complement inhibitors in the development of the immune-inflammatory process.

Aran Perramon, Jose Maria (Director)

2011

Fetal gene transfer in the pregnant rabbit model. Optimization of retroviral vectors for a higher efficiency, safety and persistence of transgene expression

Aran Perramon, Jose Maria (Director)

2008

Heterogeneous functional behavior of missense mutations in the N-terminus of CFTR

Aran Perramon, Jose Maria (Director)

2008

Role of the CD40 receptor in endothelial cell activation. Relevance of the CD40-CD40L interaction in immune-inflammatory processes. PhD STUDENT: Raquel Pluvinet Ortega

Aran Perramon, Jose Maria (Director)

2007

CFTR gene repair as therapeutic strategy for cystic fibrosis

Aran Perramon, Jose Maria (Director)

2005

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Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):

 

NUEVA ACTIVIDAD ANTI-INFLAMATORIA E INMUNOMODULADORA DE C4BP Y FACTOR H: POTENCIAL DIAGNÓSTICO Y TERAPÉUTICO EN PROCESOS INMUNO-INFLAMATORIOS

PI13/01490. 01/2014-09/2017. 113.000 €. IP: Josep Mª Aran Perramon.

Los actuales fármacos anti-inflamatorios e inmunosupresores, dirigidos al sistema inmune de pacientes con procesos inmunoinflamatorios para restaurar su homeostasis, inducen efectos adversos e inespecíficos importantes. Por tanto, son necesarios nuevos agentes inmunomoduladores más eficientes, selectivos y seguros. Se pretende profundizar en los mecanismos de acción y en la aplicabilidad de C4BP(beta-) y el factor FH como prometedores agentes biológicos anti-inflamatorios e inmunomoduladores, y como potenciales biomarcadores de procesos inmuno-inflamatorios.