• Mechanisms involved in the pro-angiogenic effect of TGF-beta, EGF and VEGF.
  • Metronomic administration of chemotherapy agents as antiangiogenic therapy.
  • Research into non-invasive biomarkers in clinical trials with antiangiogenics.
  • Mechanisms of resistance and invasion in response to antiangiogenic therapies in animal models and in human tumours.
  • Signalling pathways in angiogenesis.

Quantification of gold nanoparticle accumulation in tissue by two-photon luminescence microscopy

Morales-Dalmau J., Vilches C., Sanz V., De Miguel I., Rodríguez-Fajardo V., Berto P., Martínez-Lozano M., Casanovas O., Durduran T., Quidant R.

2019

A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients.

García M, Moreno R, Gil-Martin M, Cascallò M, de Olza MO, Cuadra C, Piulats JM, Navarro V, Domenech M, Alemany R, Salazar R

HUMAN GENE THERAPY. (ISSN/ISBN: 10430342).

2019

PIK3CA mutations in vascular malformations

Castillo SD, Baselga E, Graupera M

CURRENT OPINION IN HEMATOLOGY. (ISSN/ISBN: 10656251). 26(3): 170-178

2019

Phase II Study of Everolimus and Octreotide LAR in Patients with Nonfunctioning Gastrointestinal Neuroendocrine Tumors: The GETNE1003_EVERLAR study.

Capdevila J, Teulé A, Barriuso J, Castellano D, Lopez C, Manzano JL, Alonso V, García-Carbonero R, Dotor E, Matos I, Custodio A, Casanovas O, Salazar R, EVERLAR study investigators

ONCOLOGIST. (ISSN/ISBN: 10837159).

2019

Insulin-like growth factor levels and chronic lymphocytic leukaemia: results from the MCC-Spain and EpiLymph-Spain studies

Casabonne D, Benavente Y, Costas L, Robles C, Gonzalez-Barca E, de la Banda E, Alonso E, Aymerich M, Campo E, Marcos-Gragera R, Tardón A, Olmedo-Requena R, Gimeno E, Martínez-López A, Casanovas O, Castaño-Vinyals G, Aragonés N, Pollán M, Kogevinas M, de Sanjosé S

BRITISH JOURNAL OF HAEMATOLOGY. (ISSN/ISBN: 00071048).

2019

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

Di Mitri D, Mirenda M, Vasilevska J, Calcinotto A, Delaleu N, Revandkar A, Gil V, Boysen G, Losa M, Mosole S, Pasquini E, D'Antuono R, Masetti M, Zagato E, Chiorino G, Ostano P, Rinaldi A, Gnetti L, Graupera M, Martins Figueiredo Fonseca A, Pereira Mestre R, Waugh D, Barry S, De Bono J, Alimonti A

2019

Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?

Castet F, Garcia-Mulero S, Sanz-Pamplona R, Cuellar A, Casanovas O, Caminal JM, Piulats JM

2019

Anti-tumor effects of anti-Semaphorin 4D antibody unravel a novel pro-invasive mechanism of vascular targeting agents

Zuazo-Gaztelu I, Pàez-Ribes M, Carrasco P, Martin L, Soler A, Martínez-Lozano M, Pons R, Llena J, Palomero L, Graupera M, Casanovas O

2019

Non-invasive and quantitative in vivo monitoring of gold nanoparticle concentration and tissue hemodynamics by hybrid optical spectroscopies

Mireles M, Morales-Dalmau J, Johansson JD, Vidal-Rosas EE, Vilches C, Martínez-Lozano M, Sanz V, de Miguel I, Casanovas O, Quidant R, Durduran T

NANOSCALE. (ISSN/ISBN: 20403364).

2019

Phase II study of high-sensitivity genotyping of KRAS, NRAS, BRAF and PIK3CA to ultra-select metastatic colorectal cancer patients for panitumumab plus FOLFIRI: the ULTRA trial

Santos C, Azuara D, Viéitez JM, Páez D, Falcó E, Élez E, López-López C, Valladares M, Robles-Díaz L, García-Alfonso P, Bugés C, Durán G, Salud A, Navarro V, Capellá G, Aranda E, Salazar R

ANNALS OF ONCOLOGY. (ISSN/ISBN: 09237534).

2019

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Vulnerabilities of Tumour and Stroma Interactions in Castration-Naïve Metastatic Prostate Cancer (PROSTARGET)

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Entitat finançadora:
  • ASOCIACIÓN ESPAÑOLA CONTRA EL CÁNCER

2018-10-01 - 2023-09-30

Mitochondrial fusion in endotelial cells: impact on systemic energy and glucose homeostasis

Graupera Garcia Mila, Mariona (Participante)

2018-03-01 - 2020-02-29

Desarrollo de un nuevo biomarcador y su kit para predecir la Resistencia a Antiangiogénicos en Cancer - AngioBIOMARK

Casanovas Casanovas, Oriol (Investigador principal (IP))

Ref.: DTS17/00194

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2018-01-01 - 2019-12-31

Interacció Tumor Estroma en Resistència Terapèutica (ITERT)

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Entitat finançadora:
  • CATALAN GOVERNMENT

2018-01-01 - 2020-12-31

Oncogenic vascular malformations from biology to modelling

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: SAF2017-89116R

Entitat finançadora:
  • SPANISH MINISTRY OF ECONOMY AND SCIENCE

2018-01-01 - 2020-12-31

Interacció Tumor Estroma i Resistència Terapèutica - ITERT

Casanovas Casanovas, Oriol (Investigador principal (IP))

Entitat finançadora:
  • AGAUR-GENERAL.CATALUNYA

2018-01-01 - 2020-12-31

Malformaciones vasculares oncogenicas desde la biología hasta su modelado

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Entitat finançadora:
  • MINISTERIO DE EDUCACIÓN Y CIENCIA

2018-01-01 - 2020-12-31

Unravelling the interdependency between PI3K/PTEN signalling and cell metabolism in promoting endothelial cell activation in white adipose tissue

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: SAF2017-82072-ERC

Entitat finançadora:
  • SPANISH MINISTRY OF ECONOMY AND SCIENCE
  • MINISTERIO DE EDUCACIÓN Y CIENCIA

2017-12-01 - 2018-11-30

PI3K y pericitos en el desarrollo de la retinopatía diabética

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: IN[17]_BBM_TRA_0350

Entitat finançadora:
  • FUNDACIÓN BBVA

2017-09-15 - 2019-03-15

PI3-Kinasa y pericitos en el desarrollo de la retinopatía diabética

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: BBM_TRA_0350

Entitat finançadora:
  • BBVA

2017-09-01 - 2019-04-30

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Role of systemic metabolic disturbances induced my alteration in endothelial cells

Graupera Garcia Mila, Mariona (Codirector) Doctorando: Iñigo Chivite Araiz

2019

Dual effect of Semaphorin 4D blockade in neuroendocrine tumor malignization: from vessels to macrophages

Casanovas Casanovas, Oriol (Director) Doctorando: Iratxe Zuazo Gaztelu

2018

Prognostic markers and therapeutic targets for metastatic renal cell carcinoma

Casanovas Casanovas, Oriol (Director) Doctorando: Mariona Bartroli Comellas

2018

Deciphering the role of endothelial cells in the regulation of physiological and pathological white adipose tissue remodelling

Graupera Garcia Mila, Mariona (Director) Doctorando: Erika Monelli

2017

Deciphering the role of endothelial cells in the regulation of physiological and pathological white adipose tissue remodelling

Graupera Garcia Mila, Mariona (Director) Doctorando: Erika Monelli

2017

Role of PI3K in pericytes during the angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: ANA RAQUEL MARTINS FIGUEIREDO

2017

Role of PI3K in pericytes during the angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: Ana Raquel Martins Figueiredo

2017

Regulation of actomyosin contractility by p110a PI3-kinase in srouting angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: Ana Angulo-Urarte

2017

Regulation of actomyosin contractility by p110α PI3-kinase in sprouting angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: Ana Angulo Urarte

2017

NEW TARGETS IN TUMOR ANGIOGENESIS TO BLOCK TUMOR RE-GROWTH AND THERAPEUTIC RESISTANCE

Casanovas Casanovas, Oriol (Director) Doctorando: Nicklas Bassani

2017

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2015 Proof of Concept (PoC) grant from the European Research Council – Oriol Casanovas