• Mecanismes moleculars que intervenen en la migració de cèl·lules tumorals, invasió i metàstasi: paper de TGF-beta en aquests procesos (Àngels Fabra i Isabel Fabregat)

• Paper de TGF-beta en l'adquisició de propietats de cèl·lules mare tumorals. (Àngels Fabra i Isabel Fabregat)

• Paper de la família NADPH oxidasa (NOX) com a mediador d'efectes TGF-beta (Isabel Fabregat)

• MicroRNAs com a reguladors del nucli metastàtic: creuament amb la via TGF-beta (Àngels Fabra)

 

Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis

Fabregat I; Caballero-Diaz D

FRONTIERS IN ONCOLOGY. (ISSN/ISBN: 2234943X). 8(SEP): 357-

2018

Corrigendum to European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) [Redox Biol. 13 (2017) 94-162]

Egea J; Fabregat I; Frapart Y; Ghezzi P; Gorlach A; Kietzmann T; Kubaichuk K; Knaus U; Lopez M; Olaso-Gonzalez G; Petry A; Schulz R; Viña J; Winyard P; Abbas K; Ademowo O; Afonso C; Andreadou I; Antelmann H; Antunes F; Aslan M; Bachschmid M; Barbosa R; Belousov V; Berndt C; Bernlohr D; Bertran E; Bindoli A; Bottari S; Brito P; Carrara G; Casas A; Chatzi A; Chondrogianni N; Conrad M; Cooke M; Costa J; Cuadrado A; My-Chan Dang P; De Smet B

REDOX BIOLOGY (ISSN/ISBN: 22132317)

2018

REDOX STRESS IN MARFAN SYNDROME: DISSECTING THE ROLE OF THE NADPH OXIDASE NOX4 IN AORTIC ANEURYSM.

Jiménez-Altayó F, Meirelles T, Crosas-Molist E, Sorolla MA, Del Blanco DG, López-Luque J, Mas-Stachurska A, Siegert AM, Bonorino F, Barberà L, García C, Condom E, Sitges M, Rodríguez-Pascual F, Laurindo F, Schröder K, Ros J, Fabregat I, Egea G

FREE RADICAL BIOLOGY AND MEDICINE (ISSN/ISBN: 08915849)

2018

Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome

Siegert A; Serra-Peinado C; Gutierrez-Martínez E; Rodriguez-Pascual F; Fabregat I; Egea G

BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR BASIS OF DISEASE (ISSN/ISBN: 09254439). 1864 (2) : 554-562

2018

TGF-? and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

Caja L, Dituri F, Mancarella S, Caballero-Diaz D, Moustakas A, Giannelli G, Fabregat I

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (ISSN/ISBN: 14220067). 19 (5)

2018

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression.

Rani B, Malfettone A, Dituri F, Soukupova J, Lupo L, Mancarella S, Fabregat I, Giannelli G

CELL DEATH DIS (ISSN/ISBN: 20414889). 9 (3) : 373-373

2018

Secondary malignancies and survival outcomes after autologous stem cell transplantation for follicular lymphoma in the pre-rituximab and rituximab eras: a long-term follow-up analysis from the Spanish GELTAMO registry

GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea) Cooperative Study Group.; Jiménez-Ubieto A; Grande C; Caballero D; Yáñez L; Hernández-Garcia M; Novelli S; Arranz R; Ferreiro J; Bobillo S; Mercadal S; Galeo A; Jimenez J; Moraleda J; Vallejo C; Albo C; Perez E; Marrero C; Magnano L; Palomera L; Jarque I; Martinez-Sanchez P; Martin A; Coria E; López-Guillermo A; Salar A; Lahuerta J

BONE MARROW TRANSPLANTATION (ISSN/ISBN: 02683369). 1-4

2018

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo C; Caja L; Fabregat I; Mikulits W; Kardassis D; Heldin C; Moustakas A

CELL DEATH AND DIFFERENTIATION (ISSN/ISBN: 13509047). 1-19

2018

Revisiting the liver: from development to regeneration - what we ought to know!

López-Luque J, Fabregat I

THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (ISSN/ISBN: 02146282). 62 (6-7-8) : 441-451

2018

Bone Morphogenetic Protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury.

Addante A, Roncero C, Almalé L, Lazcanoiturburu N, García-Álvaro M, Fernández M, Sanz J, Hammad S, Nwosu ZC, Lee SJ, Fabregat I, Dooley S, Ten Dijke P, Herrera B, Sánchez A

LIVER INTERNATIONAL (ISSN/ISBN: 14783223)

2018

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META-CAN: Targeting the metabolism-immune system connections in Cancer

Moreno Caceres, Joaquim (Contratado/a); Muñoz Pinedo, Cristina (Coordinador/a)

Ref.: H2020-MSCA-ITN-2017GA766214

Entitat finançadora:
  • EUROPEAN COMISSION – EXCELLENT SCIENCE DEPARTMENT, MARIE SKLODOWSKA-CURIE INNOVATIVE TRAINING NETWORKS.

2017-09-01 - 2021-10-01

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Crosstalk between TGF-beta-induced epithelial-mesenchymal transition and stemness in hepatocellular carcinoma

Fabregat Romero, Maria Isabel (Director) Doctorando: Andrea Malfettone

2016

New insights into the crosstalk between the TGF-β and the EGF Receptor pathways during liver regeneration and hepatocarcinogenesis

Ramos Rubio, Emili (Director) Doctorando: Judith López Luque; Fabregat Romero, Maria Isabel (Director) Doctorando: Judith López Luque

2016

The role of caveolin-1 in the TGF-β-induced signaling in hepatocycles

Fabregat Romero, Maria Isabel (Director) Doctorando: Joaquin Moreno Cáceres

2016

Mechanisms regulating CXCR4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the TGF-ß pathway

Navarro Gomez, Estanislao (Director) Doctorando: Edgar B. Cepeda; Fabregat Romero, Maria Isabel (Director) Doctorando: Edgar B. Cepeda

2015

Role of the NADPH oxidase NOX4 in liver fibrosis and hepatocarcinogenesis

Bertran Rodriguez, Esther (Director) Doctorando: Eva Crosas Molist; Fabregat Romero, Maria Isabel (Director) Doctorando: Eva Crosas Molist

2015

Molecular mechanisms involved in hepatocellular carcinoma cell response to sorafenib

Patricia Sancho (Director) Doctorando: Joan Fernando Peidró; Fabregat Romero, Maria Isabel (Director) Doctorando: Joan Fernando Peidró

2013

TGF-?-regulated genes implicated in invasion that might participate in the control of apoptosis in liver tumor cells

Fabra Fres, Angels (Director) Doctorando: Jessica Mainez Villoro; Fabregat Romero, Maria Isabel (Director) Doctorando: Jessica Mainez Villoro

2012

Estudio de la contribución de la proteína SPARC a los procesos de invasión y metástasis

Fabra Fres, Angels (Director) Doctorando: Olga de la Caridad Jorge Torres

2012

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  • Coordinació del consorci europeu IT-LIVER (inhibició de TGF-β en malalties del fetge) - programa de Marie Curie ITN.
  • Projectes nacionals (Pla Estatal, FIS), fundacions privades (Marató TV3 i AECC) i projectes amb empreses farmacèutiques (Digna - Espanya, 4SC AG-Alemanya)