• Mecanismes moleculars que intervenen en la migració de cèl·lules tumorals, invasió i metàstasi: paper de TGF-beta en aquests procesos (Àngels Fabra i Isabel Fabregat)

• Paper de TGF-beta en l'adquisició de propietats de cèl·lules mare tumorals. (Àngels Fabra i Isabel Fabregat)

• Paper de la família NADPH oxidasa (NOX) com a mediador d'efectes TGF-beta (Isabel Fabregat)

• MicroRNAs com a reguladors del nucli metastàtic: creuament amb la via TGF-beta (Àngels Fabra)

 

c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial–Mesenchymal Transition and Regulates Cell Phenotypic Switch

Almalé L., García-Álvaro M., Martínez-Palacián A., García-Bravo M., Lazcanoiturburu N., Addante A., Roncero C., Sanz J., de la O López M., Bragado P., Mikulits W., Factor V., Thorgeirsson S., Casal J., Segovia J., Rial E., Fabregat I., Herrera B., Sánchez A.

2019

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition

López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E, Sanz-Moreno V, Fabregat I

2019

Clinical predictors of survival in metastatic uveal melanoma

Lorenzo D, Piulats JM, Ochoa M, Arias L, Gutiérrez C, Català J, Cobos E, Garcia-Bru P, Dias B, Padrón-Pérez N, Caminal JM

JAPANESE JOURNAL OF OPHTHALMOLOGY. (ISSN/ISBN: 00215155).

2019

Paradoxical role of the NADPH oxidase NOX4 in early preneoplastic stages of hepatocytes induced by amino acid deprivation

Campisano S, Bertran E, Caballero-Díaz D, La Colla A, Fabregat I, Chisari AN

BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. (ISSN/ISBN: 03044165).

2019

Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis

Fabregat I., Caballero-Díaz D.

FRONTIERS IN ONCOLOGY. (ISSN/ISBN: 2234943X). 8(SEP): 357-

2018

REDOX STRESS IN MARFAN SYNDROME: DISSECTING THE ROLE OF THE NADPH OXIDASE NOX4 IN AORTIC ANEURYSM.

Jiménez-Altayó F, Meirelles T, Crosas-Molist E, Sorolla MA, Del Blanco DG, López-Luque J, Mas-Stachurska A, Siegert AM, Bonorino F, Barberà L, García C, Condom E, Sitges M, Rodríguez-Pascual F, Laurindo F, Schröder K, Ros J, Fabregat I, Egea G

FREE RADICAL BIOLOGY AND MEDICINE (ISSN/ISBN: 08915849)

2018

Corrigendum to European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) [Redox Biol. 13 (2017) 94-162]

Egea J., Fabregat I., Frapart Y., Ghezzi P., Görlach A., Kietzmann T., Kubaichuk K., Knaus U., Lopez M., Olaso-Gonzalez G., Petry A., Schulz R., Vina J., Winyard P., Abbas K., Ademowo O., Afonso C., Andreadou I., Antelmann H., Antunes F., Aslan M., Bachschmid M., Barbosa R., Belousov V., Berndt C., Bernlohr D., Bertrán E., Bindoli A., Bottari S., Brito P., Carrara G., Casas A., Chatzi A., Chondrogianni N., Conrad M., Cooke M., Costa J., Cuadrado A., My-Chan Dang P., De Smet B., Egea J., Fabregat I., Frapart Y., Ghezzi P., Görlach A., Kietzmann T., Kubaichuk K., Knaus U., Lopez M., Olaso-Gonzalez G., Petry A., Schulz R., Vina J., Winyard P., Abbas K., Ademowo O., Afonso C., Andreadou I., Antelmann H., Antunes F., Aslan M., Bachschmid M., Barbosa R., Belousov V., Berndt C., Bernlohr D., Bertrán E., Bindoli A., Bottari S., Brito P., Carrara G., Casas A., Chatzi A., Chondrogianni N., Conrad M., Cooke M., Costa J., Cuadrado A., My-Chan Dang P., De Smet B., Egea J., Fabregat I., Frapart Y., Ghezzi P., Görlach A., Kietzmann T., Kubaichuk K., Knaus U., Lopez M., Olaso-Gonzalez G., Petry A., Schulz R., Vina J., Winyard P., Abbas K., Ademowo O., Afonso C., Andreadou I., Antelmann H., Antunes F.

REDOX BIOLOGY (ISSN/ISBN: 22132317)

2018

SPARC and miR-29ab: Friends or foes in melanoma metastasis

Ferreres, J. R.; Vinyals, A.; Cabre, E.; Pardo, I.; Adria, J.; Marcoval, J.; Fabra, A.;

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. (ISSN/ISBN: 11073756). 42S32-S32

2018

Secondary malignancies and survival outcomes after autologous stem cell transplantation for follicular lymphoma in the pre-rituximab and rituximab eras: a long-term follow-up analysis from the Spanish GELTAMO registry

Jiménez-Ubieto A, Grande C, Caballero D, Yáñez L, Hernández-Garcia MT, Novelli S, Arranz R, Ferreiro JJ, Bobillo S, Mercadal S, Galeo A, Jiménez JL, Moraleda JM, Vallejo C, Albo C, Pérez E, Marrero C, Magnano L, Palomera L, Jarque I, Martínez-Sánchez P, Martín A, Coria E, López-Guillermo A, Salar A, Lahuerta JJ, GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea) Cooperative Study Group.

BONE MARROW TRANSPLANTATION (ISSN/ISBN: 02683369). 1-4

2018

Revisiting the liver: from development to regeneration - what we ought to know!

López-Luque J, Fabregat I

THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (ISSN/ISBN: 02146282). 62 (6-7-8) : 441-451

2018

See full list

META-CAN: Targeting the metabolism-immune system connections in Cancer

Moreno Caceres, Joaquim (Contratado/a); Muñoz Pinedo, Cristina (Coordinador/a)

Ref.: H2020-MSCA-ITN-2017GA766214

Entitat finançadora:
  • EUROPEAN COMISSION – EXCELLENT SCIENCE DEPARTMENT, MARIE SKLODOWSKA-CURIE INNOVATIVE TRAINING NETWORKS.

2017-09-01 - 2021-10-01

See full list

Bases moleculars i estratègies terapèutiques contra les metàstasis del melanova uveal

Fabra Fres, Angels (Director) Doctorando: Eduard Cabre Estivill

2018

New experimental approaches to study the relevance of the tgf-b and egfr signalling during liver tumourogenesis

Fabregat Romero, Maria Isabel (Director) Doctorando: Daniel Caballero Díaz

2018

Crosstalk between TGF-beta-induced epithelial-mesenchymal transition and stemness in hepatocellular carcinoma

Fabregat Romero, Maria Isabel (Director) Doctorando: Andrea Malfettone

2016

New insights into the crosstalk between the TGF-β and the EGF Receptor pathways during liver regeneration and hepatocarcinogenesis

Ramos Rubio, Emili (Director) Doctorando: Judith López Luque; Fabregat Romero, Maria Isabel (Director) Doctorando: Judith López Luque

2016

The role of caveolin-1 in the TGF-β-induced signaling in hepatocycles

Fabregat Romero, Maria Isabel (Director) Doctorando: Joaquin Moreno Cáceres

2016

Mechanisms regulating CXCR4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the TGF-ß pathway

Navarro Gomez, Estanislao (Director) Doctorando: Edgar B. Cepeda; Fabregat Romero, Maria Isabel (Director) Doctorando: Edgar B. Cepeda

2015

Role of the NADPH oxidase NOX4 in liver fibrosis and hepatocarcinogenesis

Bertran Rodriguez, Esther (Director) Doctorando: Eva Crosas Molist; Fabregat Romero, Maria Isabel (Director) Doctorando: Eva Crosas Molist

2015

Molecular mechanisms involved in hepatocellular carcinoma cell response to sorafenib

Patricia Sancho (Director) Doctorando: Joan Fernando Peidró; Fabregat Romero, Maria Isabel (Director) Doctorando: Joan Fernando Peidró

2013

TGF-?-regulated genes implicated in invasion that might participate in the control of apoptosis in liver tumor cells

Fabra Fres, Angels (Director) Doctorando: Jessica Mainez Villoro; Fabregat Romero, Maria Isabel (Director) Doctorando: Jessica Mainez Villoro

2012

Estudio de la contribución de la proteína SPARC a los procesos de invasión y metástasis

Fabra Fres, Angels (Director) Doctorando: Olga de la Caridad Jorge Torres

2012

See full list

  • Coordinació del consorci europeu IT-LIVER (inhibició de TGF-β en malalties del fetge) - programa de Marie Curie ITN.
  • Projectes nacionals (Pla Estatal, FIS), fundacions privades (Marató TV3 i AECC) i projectes amb empreses farmacèutiques (Digna - Espanya, 4SC AG-Alemanya)