• Mecanismes moleculars que intervenen en la migració de cèl·lules tumorals, invasió i metàstasi: paper de TGF-beta en aquests procesos (Àngels Fabra i Isabel Fabregat)

• Paper de TGF-beta en l'adquisició de propietats de cèl·lules mare tumorals. (Àngels Fabra i Isabel Fabregat)

• Paper de la família NADPH oxidasa (NOX) com a mediador d'efectes TGF-beta (Isabel Fabregat)

• MicroRNAs com a reguladors del nucli metastàtic: creuament amb la via TGF-beta (Àngels Fabra)

 

Clinical predictors of survival in metastatic uveal melanoma

Lorenzo D, Piulats JM, Ochoa M, Arias L, Gutiérrez C, Català J, Cobos E, Garcia-Bru P, Dias B, Padrón-Pérez N, Caminal JM

JAPANESE JOURNAL OF OPHTHALMOLOGY. (ISSN/ISBN: 00215155).

2019

Paradoxical role of the NADPH oxidase NOX4 in early preneoplastic stages of hepatocytes induced by amino acid deprivation

Campisano S, Bertran E, Caballero-Díaz D, La Colla A, Fabregat I, Chisari AN

BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. (ISSN/ISBN: 03044165).

2019

Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis

Fabregat I., Caballero-Díaz D.

FRONTIERS IN ONCOLOGY. (ISSN/ISBN: 2234943X). 8(SEP): 357-

2018

REDOX STRESS IN MARFAN SYNDROME: DISSECTING THE ROLE OF THE NADPH OXIDASE NOX4 IN AORTIC ANEURYSM.

Jiménez-Altayó F, Meirelles T, Crosas-Molist E, Sorolla MA, Del Blanco DG, López-Luque J, Mas-Stachurska A, Siegert AM, Bonorino F, Barberà L, García C, Condom E, Sitges M, Rodríguez-Pascual F, Laurindo F, Schröder K, Ros J, Fabregat I, Egea G

FREE RADICAL BIOLOGY AND MEDICINE (ISSN/ISBN: 08915849)

2018

Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma.

Lorenzo D, Ochoa M, Piulats JM, Gutiérrez C, Arias L, Català J, Grau M, Peñafiel J, Cobos E, Garcia-Bru P, Rubio MJ, Padrón-Pérez N, Dias B, Pera J, Caminal JM

CANCER RES TREAT. (ISSN/ISBN: 15982998).

2018

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression.

Rani B, Malfettone A, Dituri F, Soukupova J, Lupo L, Mancarella S, Fabregat I, Giannelli G

CELL DEATH DIS (ISSN/ISBN: 20414889). 9 (3) : 373-373

2018

Corrigendum to European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) [Redox Biol. 13 (2017) 94-162]

Egea J., Fabregat I., Frapart Y., Ghezzi P., Görlach A., Kietzmann T., Kubaichuk K., Knaus U., Lopez M., Olaso-Gonzalez G., Petry A., Schulz R., Vina J., Winyard P., Abbas K., Ademowo O., Afonso C., Andreadou I., Antelmann H., Antunes F., Aslan M., Bachschmid M., Barbosa R., Belousov V., Berndt C., Bernlohr D., Bertrán E., Bindoli A., Bottari S., Brito P., Carrara G., Casas A., Chatzi A., Chondrogianni N., Conrad M., Cooke M., Costa J., Cuadrado A., My-Chan Dang P., De Smet B., Egea J., Fabregat I., Frapart Y., Ghezzi P., Görlach A., Kietzmann T., Kubaichuk K., Knaus U., Lopez M., Olaso-Gonzalez G., Petry A., Schulz R., Vina J., Winyard P., Abbas K., Ademowo O., Afonso C., Andreadou I., Antelmann H., Antunes F., Aslan M., Bachschmid M., Barbosa R., Belousov V., Berndt C., Bernlohr D., Bertrán E., Bindoli A., Bottari S., Brito P., Carrara G., Casas A., Chatzi A., Chondrogianni N., Conrad M., Cooke M., Costa J., Cuadrado A., My-Chan Dang P., De Smet B., Egea J., Fabregat I., Frapart Y., Ghezzi P., Görlach A., Kietzmann T., Kubaichuk K., Knaus U., Lopez M., Olaso-Gonzalez G., Petry A., Schulz R., Vina J., Winyard P., Abbas K., Ademowo O., Afonso C., Andreadou I., Antelmann H., Antunes F.

REDOX BIOLOGY (ISSN/ISBN: 22132317)

2018

Secondary malignancies and survival outcomes after autologous stem cell transplantation for follicular lymphoma in the pre-rituximab and rituximab eras: a long-term follow-up analysis from the Spanish GELTAMO registry

Jiménez-Ubieto A., Grande C., Caballero D., Yáñez L., Hernández-Garcia M., Novelli S., Arranz R., Ferreiro J., Bobillo S., Mercadal S., Galeo A., Jiménez J., Moraleda J., Vallejo C., Albo C., Pérez E., Marrero C., Magnano L., Palomera L., Jarque I., Martínez-Sánchez P., Martín A., Coria E., López-Guillermo A., Salar A., Lahuerta J.

BONE MARROW TRANSPLANTATION (ISSN/ISBN: 02683369). 1-4

2018

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo C., Caja L., Fabregat I., Mikulits W., Kardassis D., Heldin C., Moustakas A.

CELL DEATH AND DIFFERENTIATION (ISSN/ISBN: 13509047). 1-19

2018

TGF-? and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

Caja L, Dituri F, Mancarella S, Caballero-Diaz D, Moustakas A, Giannelli G, Fabregat I

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (ISSN/ISBN: 14220067). 19 (5)

2018

See full list

META-CAN: Targeting the metabolism-immune system connections in Cancer

Moreno Caceres, Joaquim (Contratado/a); Muñoz Pinedo, Cristina (Coordinador/a)

Ref.: H2020-MSCA-ITN-2017GA766214

Entitat finançadora:
  • EUROPEAN COMISSION – EXCELLENT SCIENCE DEPARTMENT, MARIE SKLODOWSKA-CURIE INNOVATIVE TRAINING NETWORKS.

2017-09-01 - 2021-10-01

See full list

Crosstalk between TGF-beta-induced epithelial-mesenchymal transition and stemness in hepatocellular carcinoma

Fabregat Romero, Maria Isabel (Director) Doctorando: Andrea Malfettone

2016

New insights into the crosstalk between the TGF-β and the EGF Receptor pathways during liver regeneration and hepatocarcinogenesis

Ramos Rubio, Emili (Director) Doctorando: Judith López Luque; Fabregat Romero, Maria Isabel (Director) Doctorando: Judith López Luque

2016

The role of caveolin-1 in the TGF-β-induced signaling in hepatocycles

Fabregat Romero, Maria Isabel (Director) Doctorando: Joaquin Moreno Cáceres

2016

Mechanisms regulating CXCR4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the TGF-ß pathway

Navarro Gomez, Estanislao (Director) Doctorando: Edgar B. Cepeda; Fabregat Romero, Maria Isabel (Director) Doctorando: Edgar B. Cepeda

2015

Role of the NADPH oxidase NOX4 in liver fibrosis and hepatocarcinogenesis

Bertran Rodriguez, Esther (Director) Doctorando: Eva Crosas Molist; Fabregat Romero, Maria Isabel (Director) Doctorando: Eva Crosas Molist

2015

Molecular mechanisms involved in hepatocellular carcinoma cell response to sorafenib

Patricia Sancho (Director) Doctorando: Joan Fernando Peidró; Fabregat Romero, Maria Isabel (Director) Doctorando: Joan Fernando Peidró

2013

TGF-?-regulated genes implicated in invasion that might participate in the control of apoptosis in liver tumor cells

Fabra Fres, Angels (Director) Doctorando: Jessica Mainez Villoro; Fabregat Romero, Maria Isabel (Director) Doctorando: Jessica Mainez Villoro

2012

Estudio de la contribución de la proteína SPARC a los procesos de invasión y metástasis

Fabra Fres, Angels (Director) Doctorando: Olga de la Caridad Jorge Torres

2012

See full list

  • Coordinació del consorci europeu IT-LIVER (inhibició de TGF-β en malalties del fetge) - programa de Marie Curie ITN.
  • Projectes nacionals (Pla Estatal, FIS), fundacions privades (Marató TV3 i AECC) i projectes amb empreses farmacèutiques (Digna - Espanya, 4SC AG-Alemanya)