Huntington's disease is a neurodegenerative disorder that causes involuntary movements, psychiatric disturbances, and dementia, caused by a mutation in the huntingtin gene (HTT) consisting of expansion of the number of repeats of a CAG (cytosine-adenine-guanine) triplet. The study, realized by CIBERNED researchers at Center for Molecular Biology Severo Ochoa and IDIBELL, has been published this week at Nature Medicine.

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry