CMR[B] Lecture Series: Cell fate control at the chromatin level
Duanqing Pei, PhD
Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, in Guangzhou, China
Title: “Cell fate control at the chromatin level”
Professor Duanqing Pei is an Associate Member of European Molecular Biology Organization (EMBO), Academic Director and former Director General of Guangzhou Institutes of Biomedicine and Health, CAS, Guangzhou, China. He is the founding executive director of the newly established Guangzhou Regenerative Medicine and Health Guangdong Laboratory, a new initiative in response to the National Lab System in China.
Upon returning to China, he started to work on stem cell pluripotency first and then reprogramming. The Pei lab was the first in China to create mouse iPSCs using a non-selective system, and then improved the iPS process systematically. His lab demonstrated that switching identity between mesenchymal and epithelial cells such as EMT and MET is essential in both reprogramming and differentiation; Vitamin C acts through DNA and histone demethylases to remove epigenetic barriers in reprogramming cells during iPSC generation; and a simple open/close mechanism that governs the chromatin accessibility dynamics associated with both Yamanaka and chemical induction of pluripotency (YIP and CIP). Now, his lab continues to explore new ways to understand and manipulate cell fate, utilize these cutting edge technology to cure diseases.
Dr. Pei has received many awards, including twice National Award for Natural Sciences (2013 and 2018) and Outstanding Science and Technology Achievement Prize of the Chinese Academy of Science (2017).