• To define a more precise and personalised treatment by defining new molecular prognostic and predictive tools for patients with squamous-cell carcinoma (SCC).
  • To define markers of detection and prognosis of HPV-induced oropharyngeal SCC, in order to obtain an early diagnosis and personalised treatment for this group of patients.
  • To find treatment biomarkers for induced late toxicity, in order to prevent and treat this appropriately.
  • To implement the use of immunotherapy for oropharyngeal SCC.
  • To improve transoral head and neck surgery to lead to an improvement in quality of life, with safe results.

PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma

Bernat-Peguera A, Simón-Extremera P, da Silva-Diz V, López de Munain M, Díaz-Gil L, Penin RM, González-Suárez E, Pérez Sidelnikova D, Bermejo O, Viñals JM, Viñals F, Muñoz P

ONCOGENE. (ISSN/ISBN: 09509232).

2019

Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1-Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial

Siu LL, Even C, Mesía R, Remenar E, Daste A, Delord JP, Krauss J, Saba NF, Nabell L, Ready NE, Braña I, Kotecki N, Zandberg DP, Gilbert J, Mehanna H, Bonomi M, Jarkowski A, Melillo G, Armstrong JM, Wildsmith S, Fayette J

JAMA ONCOL. (ISSN/ISBN: 23742445).

2019

The emergence of long-term survivors in recurrent and metastatic squamous cell head and neck cancer

Castet F, Brenes J, Taberna M, Mesía R

CURRENT OPINION IN ONCOLOGY. (ISSN/ISBN: 10408746).

2019

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort

Gomez-Armayones S, Chimenos-Küstner E, Marí A, Tous S, Penin R, Clavero O, Quirós B, Pavon MA, Taberna M, Alemany L, Servitje O, Mena M

PLOS ONE. (ISSN/ISBN: 1932-6203). 14(1): E0210070-E0210070

2019

May oral HPV in healthy individuals explain differences in HPV-attributable fractions in oropharyngeal cancer? A systematic review and meta-analysis

Mena M, Taberna M, Monfil L, Arbyn M, de Sanjosé S, Bosch FX, Alemany L, Bruni L

JOURNAL OF INFECTIOUS DISEASES. (ISSN/ISBN: 00221899).

2019

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single-arm trial

Buckland G, Travier N, Arribas L, Del Barco S, Pernas S, Zamora E, Bellet M, Cirauqui B, Margelí M, Muñoz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Valverde Y, Jansen E, Chajès V, Castro C, Agudo A

JOURNAL OF HUMAN NUTRITION AND DIETETICS. (ISSN/ISBN: 09523871).

2019

Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis

Mora P, Pons A, Cos M, Camins A, Muntané A, Aguilera C, Arús C, Majós C

EUROPEAN RADIOLOGY. (ISSN/ISBN: 09387994).

2019

Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy

Zandberg D., Algazi A., Jimeno A., Good J., Fayette J., Bouganim N., Ready N., Clement P., Even C., Jang R., Wong S., Keilholz U., Gilbert J., Fenton M., Braña I., Henry S., Remenar E., Papai Z., Siu L., Jarkowski A., Armstrong J., Asubonteng K., Fan J., Melillo G., Mesía R.

EUROPEAN JOURNAL OF CANCER. (ISSN/ISBN: 09598049). 107142-152

2019

Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

Lop J, García J, López M, Taberna M, Mena M, Alemany L, Quer M, León X

HEAD AND NECK. (ISSN/ISBN: 01486403).

2019

Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma

Acuña G, Gomà M, Temprana-Salvador J, Garcia-Bragado F, Alós L, Ordi J, Cardesa A, Nadal A

MODERN PATHOLOGY. (ISSN/ISBN: 08933952).

2019

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Prevention of breast cancer recurrences through weight control, diet, and physical activity intervention (PREDICOP).

Travier, Noemie (Participante); Buckland, Genevieve Georgina (Investigador/a); Arribas Hortiguela, Lorena (Investigador/a); Agudo Trigueros, Antonio (Participante)

Entitat finançadora:
  • INSTITUTO DE SALUD CARLOS III

2016-01-01 - 2018-12-31

Elección del tratamiento óptimo en cáncer de orofaringe en función de una firma genética.

Mesia Nin, Ricard (Investigador principal (IP))

Ref.: PI15/00500

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2016-01-01 - 2018-12-31

Determinación del estatus de EGFR, PEGFR, y VPH-E5 en pacientes con carcinoma escamosos de Orofaringe (COF) UPH relacionado

Taberna Sanz, Miren (Investigador principal (IP))

Entitat finançadora:
  • MERCK

2015-06-01 - 2017-06-01

Determinación del estatus de EGFR, pEGFR y VPH-E5 en pacientes con Carcinoma Escamoso de Orofaringe (COF) VPH-relacionado.

Taberna Sanz, Miren (Investigador principal (IP))

Ref.: 15-CC-018

Entitat finançadora:
  • FUNDACIÓ SALUD 2000

2015-06-01 - 2017-05-31

Melanoma uveal y metástasis hepáticas: Estudio de factores asociados a la diseminación metastásica e implicaciones pronósticas

Goma Gallego, Montserrat (Participante)

2015-01-01 - 2017-01-01

PI13/01263 ANÁLISIS INTEGRAL DE LOS MECANISMOS EFECTORES INMUNOLÓGICOS FUNDAMENTALES Y SU EXPRESIÓN A NIVEL MOLECULAR EN EL DESARROLLO DE LA DISFUNCIÓN CRÓNICA DEL TRASPLANTE RENAL

Goma Gallego, Montserrat (Participante)

2014-01-01 - 2016-01-01

Malalties de cap i coll- Grup de recerca en oncologia de cap i coll de la unitat funcional de tumors de cap i coll de Bellvitge

Mañós Pujol, Manel (Investigador principal (IP))

Ref.: 2014SGR0746

Entitat finançadora:
  • AGENCIA DE GESTIO DAJUTS UNIVERSITARIS I DE RECERCA

2014-01-01 - 2017-04-30

Prevención de las recaídas mediante ejercicio, dieta y control de peso en pacientes con cáncer de mama.

Travier, Noemie (Participante); Buckland, Genevieve Georgina (Investigador/a); Arribas Hortiguela, Lorena (Investigador/a); Agudo Trigueros, Antonio (Investigador principal (IP))

Ref.: PI12/00335

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III
  • ISCIII - INSTITUTO DE SALUD CARLOS III

2013-01-01 - 2015-12-31

PI11/00556 miRNA y vías de coestimulación de la respuesta inmune en la lesión arteriosclerotica precoz asociada a la Enfermedad Renal Crónica

Goma Gallego, Montserrat (Participante)

2012-01-01 - 2014-12-31

NUTRITION DAY WORLDWIDE

Arribas Hortiguela, Lorena (Participante)

Ref.: PR277/12

2012-01-01 - 2012-01-01

See full list

The most relevant projects currently under way are aimed at the study of oropharyngeal cancer, particularly in HPV-positive patients, the search for biomarkers of prognosis and aggressiveness of the disease to adapt the appropriate treatment, as well as the search for a genetic signature to search for a more personalised treatment in patients with oropharyngeal cancer.