Pharmacotherapy, Pharmacogenetics and Pharmaceutical Technology

Summary

Research projects carried out by the group include pharmacokinetic-pharmacodynamic modelling and dose personalisation, the identification of gene polymorphisms as modulators of response and toxicity of the drugs, evaluation of the possible hepatoprotective and immunomodulatory effects of lipid emulsions rich in omega-3 in total parenteral nutrition, the application of nanotechnologies to new drug-administration systems and the research and development of new drug products for pediatric and orphan diseases.

520 Publications

Strategic lines

Populational pharmacokinetic-pharmacodynamic modelling and dose individualization of biologics, antimicrobials and antifungals, and chemotherapeutic drugs: identify predictive factors of exposure variability and exposure-response relationship, predict exposure and response for different dose regimens and redefine dosing strategies to increase the probability of target attainment.

Parenteral nutrition: the influence of omega-3 fatty acid supplements on the inflammatory response in complex high-surgical-risk patients, the protective role of omega-3 fatty acids in total parenteral nutrition-associated liver complications and polymorphisms associated with plasma phytosterols depuration.

Pharmacogenetics: the effect of various genetic polymorphisms on the efficacy and toxicity of treatment with several drugs such as statins, thiopurines, abacavir, tacrolimus, among others.
Pharmaceutical technology: application of nanotechnologies to new drug-administration systems, development of DNA and RNA nanoparticles as potential new agents of drug transfer and development new drugs products for orphan and pediatric diseases.

Selected Publications

Paño Pardo JR, Moreno Rodilla E, Cobo Sacristan S, Cubero Saldaña JL, Periañez Párraga L, Del Pozo León JL, Retamar Genti P, Rodríguez Oviedo A, Torres Jaén MJ, Vidal Cortes P, Colás Sanz C. Management of Patients with Suspected or Confirmed Antibiotic Allergy. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC). J Investig Allergol Clin Immunol. 2022;33(2):doi:10.18176/jiaci.0859.

Amorós Galicia L, Nardi Ricart A, Verdugo González C, Arroyo García CM, García Montoya E, Pérez Lozano P, Suñé Negre JM, Suñé Pou M. Development of a Standardized Method for Measuring Bioadhesion and Mucoadhesion That Is Applicable to Various Pharmaceutical Dosage Forms. Pharmaceutics. 2022;14(10):doi:10.3390/pharmaceutics14101995.

Ronda M, Pérez Recio S, González Laguna M, Tubau Quintano MF, Llop Talaveron J, Soldevila Boixader L, Carratalà J, Cuervo G, Padullés A. Ceftolozane/tazobactam for difficult-to-treat Gram-negative infections: A real-world tertiary hospital experience. J Clin Pharm Ther. 2022;47(7):932-939. doi:10.1111/jcpt.13623.

Romero Pinel L, Bau L, Matas E, León I, Juvany R, Jódar R, Martínez Yélamos A, Martínez Yélamos S. Cost associated with a relapse-free patient in multiple sclerosis: A real-world health indicator. PLoS One. 2022;17(4):267504-267504. doi:10.1371/journal.pone.0267504.

Llop Talaveron J, Leiva Badosa E, Alia Ramos P, Rigo Bonnin R, Virgili Casas N, Farran Teixidor L, Miró Martín M, Garrido Sanchez L, Suárez Lledó A, Badía Tahull MB. Genetic factors associated with alterations in liver function test results in adult hospitalized patients treated with parenteral nutrition: A substudy of a clinical trial. Nutrition. 2022;93111507-111507. doi:10.1016/j.nut.2021.111507.

Selected Projects

21MAR009. Catalan interhospital network of genetic variants to improve genetic diagnosis in rare diaseases. (202040-32) . FUNDACIÓ LA MARATÓ DE TV3. Budget: 26.625,00. 2021-2024. PI: PADRO MIQUEL, ARIADNA.

FIS21079. Aplicación de los modelos de cinética poblacional de tacrolimus en distintas poblaciones de trasplante. Papel de los polimorfismos del CYP3A en el trasplante de renal y trasplante hepático (adulto y pediátrico). INSTITUTO DE SALUD CARLOS III (ISCIII). Budget: 200206,6. 2022-2024. PI: COLOM CODINA, HELENA i LLOBERAS BLANC, NURIA.

19INT001. Antibiotic plasma level concentrations during continuous renal replacement therapy with a high absorptive membrane (oXiris®). BAXTER HEALTHCARE CORPORATION. Budget: 11.065,26. 2019-2023. PI: COLOM CODINA, HELENA.

19FIS011. Mecanismos post-transcripcionales reguladores de la respuesta inflamatoria en aterosclerosis y Enfermedad Renal Crónica: Tráfico de macrófagos, polarización, formación de células espumosa (PI18/01108) . INSTITUTO DE SALUD CARLOS III (ISCIII). Budget: 220.220,00. 2019-2022. PI: SUÑE NEGRE, JOSEP MARIA.

FAR-NP-2017-01 AC012/17. ENSAYO CLÍNICO PILOTO, RANDOMIZADO, DOBLE CIEGO, PARA ESTUDIAR EL EFECTO DE LA SUPLEMENTACIÓN PARENTERAL CON EMULSIÓN DE ACEITE DE PESCADO EN EL SOPORTE NUTRICIONAL EN PACIENTES ESOFAGECTOMIZADOS. BADIA TAHULL, MARIA BELLA. Budget: 0. 2018-2022. PI: BADIA TAHULL, MARIA BELLA.

More Information

Our IDIBELL research group works in close collaboration with researchers at the School of Pharmacy of the University of Barcelona (Service of Drug Development [SDM] and the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry. The SDM within the School of Pharmacy collaborates with pharmaceutical and other related industries in the field of Pharmaceutical Technology. Other non-competitive contracts or agreements with companies managed through The Bosch i Gimpera Foundation have been performed by the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry in the field of Pharmacokinetics.

Patents: Patente de invención (Europea). Título de la invención: Descongestant and bilastine drugs delivery system. Inventores: J.Mª Suñé Negre, M Roig Carreras, F Gual Pujol, P Marcianes, I Ortega Azpitarte, G Hernández Herrrero. Solicitante: FAES FARMA, SA.
Número de registro: EP 20382701.9 (Prioridad XX.XX.2020). Fecha de presentación: 30 de julio de 2020. Lugar de presentación: Canadian Intellectual Property Office.

Doctoral theses directed by a member of the group and read or diposited in 2020: 6 PhD students successfully defended their theses. Active doctoral theses directed by a member of the group: 10 PhD students.

Several members of our group are involved in teaching activities for degrees, Master degrees and specialized courses since 2015. In a proposal of continuous training, members of our team yearly attend to international and national workshops organized by scientific organisms.