• Identification of metastatic agents and the study of their biological role in developing sarcomas.
  • Identification of new therapeutic targets and preclinical evaluation of new compounds to treat sarcomas (Xavier García del Muro)
  • Identification of new prognostic markers for sarcomas (Xavier García del Muro)

Bcl-xL inhibition enhances Dinaciclib-induced cell death in soft-tissue sarcomas

Rello-Varona S, Fuentes-Guirado M, López-Alemany R, Contreras-Pérez A, Mulet-Margalef N, García-Monclús S, Tirado OM, García Del Muro X

SCI. REP.. 9(1): 3816-3816

2019

Uncovering the role of lysyl oxidase-like 2 in rhabdomyosarcoma.

Almacellas Rabaiget, Olga; Huertas Martinez, Juan; Garcia Monclus, Silvia; Rello Varona, Santiago; Herrero Martin, David; Lopez Alemany, Roser; Tirado, Oscar M.;

CLINICAL CANCER RESEARCH (ISSN/ISBN: 10780432). 24 (2) : 65-65

2018

Tumor-suppressive activities associated to MIR10A-5p expression in developmental sarcomas.

Herrero-Martin, David; Rello-Varona, Santiago; Garcia-Monclus, Silvia; Huertas-Martinez, Juan; Almacellas-Rabaiget, Olga; Helman, Lee J.; Tirado, Oscar M.;

CLINICAL CANCER RESEARCH (ISSN/ISBN: 10780432). 24 (2) : 63-64

2018

Phase II Study of Gemcitabine Plus Sirolimus in Previously Treated Patients with Advanced Soft-Tissue Sarcoma: a Spanish Group for Research on Sarcomas (GEIS) Study

Martin-Liberal J., López-Pousa A., Martínez-Trufero J., Martín-Broto J., Cubedo R., Lavernia J., Redondo A., López-Martín J., Mulet-Margalef N., Sanjuan X., Tirado Ò., Garcia-del-Muro X.

TARGETED ONCOLOGY (ISSN/ISBN: 17762596). 1-7

2018

EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma.

Garcia-Monclús S, López-Alemany R, Almacellas-Rabaiget O, Herrero-Martín D, Huertas-Martinez J, Lagares-Tena L, Alba-Pavón P, Hontecillas-Prieto L, Mora J, de Álava E, Rello-Varona S, Giangrande PH, Tirado OM

INTERNATIONAL JOURNAL OF CANCER (ISSN/ISBN: 00207136)

2018

Improved selectivity and cytotoxic effects of irinotecan via liposomal delivery: A comparative study on Hs68 and HeLa cells.

Casadó A, Mora M, Sagristá ML, Rello-Varona S, Acedo P, Stockert JC, Cañete M, Villanueva A

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (ISSN/ISBN: 09280987)

2017

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

Almazán-Moga A, Zarzosa P, Molist C, Velasco P, Pyczek J, Simon-Keller K, Giralt I, Vidal I, Navarro N, Segura MF, Soriano A, Navarro S, Tirado OM, Ferreres JC, Santamaria A, Rota R, Hahn H, Sánchez de Toledo J, Roma J, Gallego S

BRITISH JOURNAL OF CANCER (ISSN/ISBN: 00070920)

2017

DNA methylation profiling opens a new phase in the search of targeted therapy against Ewing sarcoma.

Rello-Varona S, Tirado OM

PHARMACOGENOMICS (ISSN/ISBN: 14622416). 18 (14) : 1307-1309

2017

The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma

Schwentner R; Herrero-Martin D; Kauer M; Mutz C; Katschnig A; Sienski G; Alonso J; Aryee D; Kovar H

ONCOTARGET (ISSN/ISBN: 19492553). 8 (7) : 10980-10993

2017

Correction: The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin [Oncotarget, 6, (2015), (18875-18890)]. doi: 10.18632/oncotarget.4303

Ordóñez J; Amaral A; Carcaboso A; Herrero-Martin D; García-Macias M; Sevillano V; Alonso D; Pascual-Pasto G; San-Segundo L; Vila-Ubach M; Rodrigues T; Fraile S; Teodosio C; Mayo-Iscar A; Aracil M; Galmarini C; Tirado O; Mora J; De Álav E

ONCOTARGET (ISSN/ISBN: 19492553). 8 (26) : 43592-43592

2017

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Multifunctional RNA-based reagents for the treatment of translocation-associated sarcomas

Martinez Tirado, Oscar (Investigador principal (IP))

Entitat finançadora:
  • ASOCIACIÓN ESPAÑOLA CONTRA EL CÁNCER

2018-09-01 - 2020-08-31

Recerca en Sarcomes: Metabolisme i Mort Cel.lular

Martinez Tirado, Oscar (Investigador principal (IP))

Entitat finançadora:
  • AGAUR-GENERAL.CATALUNYA

2018-01-01 - 2020-12-31

Targeting the metabolism-immune system connections in Cancer

Martinez Tirado, Oscar (Participante)

Entitat finançadora:
  • EUROPEAN COMISSION – EXCELLENT SCIENCE DEPARTMENT, MARIE SKLODOWSKA-CURIE INNOVATIVE TRAINING NETWORKS

2017-10-01 - 2021-09-30

Targeting the metabolism-immune system connections in Cancer (META-CAN)

Martinez Tirado, Oscar (Investigador principal (IP))

Entitat finançadora:
  • COMUNITAT EUROPEA

2017-09-01 - 2021-08-31

META-CAN

Martinez Tirado, Oscar (Investigador principal (IP))

Ref.: 766214METACANESR4

2017-09-01 - 2021-08-31

SUPERACIÓN DE LA RESISTENCIA A INHIBIDORES DE CICLO CELULAR EN SARCOMAS

Garcia del Muro, Solans (Investigador principal (IP))

Ref.: PI15/00234

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2016-01-01 - 2018-12-31

Mecanismos moleculares regulados por EphA2 a través de su actividad independiente de ligando durante la progresión tumoral de sarcomas pediátricos.

Martinez Tirado, Oscar (Participante)

Ref.: PI15/00025

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III
  • INSTITUTO DE SALUD CARLOS III

2016-01-01 - 2018-12-31

Moleculas de ARN multifuncionales para tratar el sarcoma de Ewing

Martinez Tirado, Oscar (Investigador principal (IP))

Ref.: DONACIÓNASOCIACIÓNALBAPEREZ

Entitat finançadora:
  • ASOCIACIÓN ALBA PÉREZ CONTRA EL CÁNCER INFANTIL

2015-09-10 - 2018-09-09

Targeted delivery of therapeutic siRNA to Ewing sarcoma junction oncogene by traceable diamond nanocrystal / antibody conjug

Martinez Tirado, Oscar (Investigador principal (IP))

Ref.: AC14/00026

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2015-01-01 - 2017-12-31

Recerca en Sarcomes: Metabolisme i Mort Cel·lular

Martinez Tirado, Oscar (Investigador principal (IP))

Ref.: 2014SGR0381

Entitat finançadora:
  • AGENCIA DE GESTIO DAJUTS UNIVERSITARIS I DE RECERCA

2014-01-01 - 2017-04-30

See full list

Caracterització funcional de loxl2 en el rabdomiosarcoma alveolar

Martinez Tirado, Oscar (Director) Doctorando: Olga Almacellas Rabaiget

2018

EPHA2 COM A DIANA TERAPÈUTICA PEL SARCOMA D’EWING

Martinez Tirado, Oscar (Director) Doctorando: Silvia Garcia Monclus

2017

Supressió tumoral guiada per components caveolars en sarcomes pediàtrics

López Alemany, Roser (Director) Doctorando: Juan Huertas Martínez; Martinez Tirado, Oscar (Director) Doctorando: Juan Huertas Martínez

2016

Combination of cytotoxic agents and targeted therapy for the treatment of advanced sarcomas: preclinical background and early clinical development

Martinez Tirado, Oscar (Director) Doctorando: Juan Martín Liberal; Garcia del Muro, Solans (Director) Doctorando: Juan Martín Liberal

2016

Creación y evolución. fundamentos para una filosofía de la creación evolutiva

Manuel Garcia Doncel (Director) Doctorando: Ricard Casadesus Castro; Garcia del Muro, Solans (Codirector) Doctorando: Ricard Casadesus Castro

2016

Miogènesi i Regeneració muscular: paper d´alfa-enolase/plasminogen i receptor del factor de creixement epitelial

López Alemany, Roser (Director) Doctorando: Anna Roig Borrellas

2014

Miogènesi i Regeneració muscular: paper d'alfa-enolase/plasminogen i receptor del factor de creixement epitelial

López Alemany, Roser (Director) Doctorando: Anna Roig Borrellas

2014

Caveolina-1 en la progresión metastásica del sarcoma de ewing

Martinez Tirado, Oscar (Director) Doctorando: Laura Maria Lagares Tena

2013

Regulación del aporte vascular en el Sarcoma de Ewing: Papel de la Caveolina-1

Martinez Tirado, Oscar (Director) Doctorando: Sáinz Jaspeado, Miguel Guillermo

2012

Estudio de las modificaciones genéticas inducidas in vivo por cisplatino en un modelo de implantación ortotópica de tumores germinales humanos.

Villanueva Garatachea, Alberto (Director) Doctorando: Jose Maria Piulats Rodríguez; Garcia del Muro, Solans (Director) Doctorando: Jose Maria Piulats Rodríguez

2010

See full list

  • Development of a new orthotopic model for studying sarcoma metastasis
  • Description of Ewing’s sarcoma methylome