• Mechanisms involved in the pro-angiogenic effect of TGF-beta, EGF and VEGF.
  • Metronomic administration of chemotherapy agents as antiangiogenic therapy.
  • Research into non-invasive biomarkers in clinical trials with antiangiogenics.
  • Mechanisms of resistance and invasion in response to antiangiogenic therapies in animal models and in human tumours.
  • Signalling pathways in angiogenesis.

The role of mTOR inhibition as second-line therapy in metastatic renal carcinoma: clinical evidence and current challenges

González-Larriba J., Maroto P., Durán I., Lambea J., Flores L., Castellano D., Anido U., Basterrechea L., Casanovas O., Chirivella I., Climent M., Dur I., Gallardo E., Garc R., Guix M., Laínez N., Marino A., Montesa Á., Pinto A., Puente J., Romero G., Suárez C., Virizuela J.

EXPERT REVIEW OF ANTICANCER THERAPY (ISSN/ISBN: 14737140). 17 (3) : 217-226

2017

Progeny of Lgr5-expressing hair follicle stem cell contributes to induced tumor development in epidermis

Da Silva-Diz, V; Sole-Sanchez, S; Valdes-Gutierrez, A; Urpi, M; Riba-Artes, D; Penin, R M; Pascual, G; Gonzalez-Suarez, E; Casanovas, O; Vinals, F; Paramio, J M; Batlle, E; Munoz, P

ONCOGENE (ISSN/ISBN: 09509232). 32 (32) : 3732-3743

2013

See full list

Mitochondrial fusion in endotelial cells: impact on systemic energy and glucose homeostasis

Graupera Garcia Mila, Mariona (Participante)

2018-03-01 - 2020-02-29

Oncogenic vascular malformations from biology to modelling

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: SAF2017-89116R

Entitat finançadora:
  • SPANISH MINISTRY OF ECONOMY AND SCIENCE

2018-01-01 - 2020-12-31

Desarrollo de un nuevo biomarcador y su kit para predecir la Resistencia a Antiangiogénicos en Cancer - AngioBIOMARK

Casanovas Casanovas, Oriol (Investigador principal (IP))

Ref.: DTS17/00194

Entitat finançadora:
  • FIS-INSTITUTO DE SALUD CARLOS III

2018-01-01 - 2019-12-31

Interacció Tumor Estroma en Resistència Terapèutica (ITERT)

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Entitat finançadora:
  • CATALAN GOVERNMENT

2018-01-01 - 2020-12-31

Unravelling the interdependency between PI3K/PTEN signalling and cell metabolism in promoting endothelial cell activation in white adipose tissue

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: SAF2017-82072-ERC

Entitat finançadora:
  • SPANISH MINISTRY OF ECONOMY AND SCIENCE

2017-12-01 - 2018-11-30

PI3K y pericitos en el desarrollo de la retinopatía diabética

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: IN[17]_BBM_TRA_0350

Entitat finançadora:
  • FUNDACIÓN BBVA

2017-09-15 - 2019-03-15

PI3-Kinasa y pericitos en el desarrollo de la retinopatía diabética

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: BBM_TRA_0350

Entitat finançadora:
  • BBVA

2017-09-01 - 2019-04-30

Activation of PI3K signalling in the pathogenesis of Vascular Anomalies

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: 2016BP00001

Entitat finançadora:
  • AGAUR-GENERAL.CATALUNYA

2017-07-01 - 2019-06-30

Activación de la vía de señalización de PI3K en la patogénesis de Anomalías Vasculares

Graupera Garcia Mila, Mariona (Investigador principal (IP))

Ref.: SLT002/16/00011

2017-07-01 - 2019-12-31

AYUDAS JUAN DE LA CIERVA - INCORPORACION 2015

VILLACAMPA ALCUBIERRE, PILAR (Investigador principal (IP))

Ref.: IJCI-2015-23455

Entitat finançadora:
  • MINISTERIO DE EDUCACIÓN Y CIENCIA

2017-02-07 - 2019-02-06

See full list

Role of systemic metabolic disturbances induced my alteration in endothelial cells

Graupera Garcia Mila, Mariona (Codirector) Doctorando: Iñigo Chivite Araiz

2019

Deciphering the role of endothelial cells in the regulation of physiological and pathological white adipose tissue remodelling

Graupera Garcia Mila, Mariona (Director) Doctorando: Erika Monelli

2017

Role of PI3K in pericytes during the angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: ANA RAQUEL MARTINS FIGUEIREDO

2017

Regulation of actomyosin contractility by p110a PI3-kinase in srouting angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: Ana Angulo-Urarte

2017

La inhibició de PI3K com a nova estratègia terapèutica antiangiogènica en la malaltia del càncer

Graupera Garcia Mila, Mariona (Director) Doctorando: Ariadna Soler Salas

2016

Role of PTEN in sprouting angiogenesis

Graupera Garcia Mila, Mariona (Director) Doctorando: Helena Serra Busquet

2014

Study of tumor malignization as a result of Semaphorin 4D blockade in a pancreatic neuroendocrine tumor mouse

Casanovas Casanovas, Oriol (Director) Doctorando: Laura Martín Mitjana

2014

Mecanismos de Resistencia al Tratamiento Anti-Angiogénico en Tumores Renales de Célula Clara

Casanovas Casanovas, Oriol (Director) Doctorando: Gabriela-Alejandra Jiménez Valerio

2013

See full list

2015 Proof of Concept (PoC) grant from the European Research Council – Oriol Casanovas