Quick test for STROKE risk diagnosis
Vulnerable atherothrombotic plaque identification using blood circulating miRNA biomarkers
Point-of-Care microfluidics paperbased analytical device (μPADs) integration (in co-development with Paperdrop Diagnostics S.L.)
This circulating biomarker can be used: 1) to detect vulnerable atherothrombotic plaque in patients with high-grade carotid artery stenosis and to predict the risk of primary and secondary ischemic stroke; 2) as a prognostic biomarker to monitor the effectiveness of the best medical treatment and for the occurrence or restenosis; and 3) for long-term management monitoring and/or outcome prediction after carotid revascularization procedures.
It is intended that health services have available a diagnostic system, based on strips of paper and colorimetry, easy to interpret, that can give a quick, cheap response (without the need for expensive imaging techniques, which are not sensitive enough) for the immediate identification and follow-up of individuals at risk, and able to reach all levels of health in the general population. Moreover, a quick diagnostic test based in our circulating miRNA, in addition to acting as a diagnostic tool, can be a key element in facilitating the decision-making of health professionals.