Hereditary Colorectal Cancer. Genetic Basis and Clinical Implications


Researchers of the Hereditary Cancer Program of the Catalan Institute of Oncology, IDIBELL (Oncobell), Dr. Laura Valle and Dr. Gabriel Capellá, together with Dr. Stephen B. Gruber of the Norris Comprehensive Cancer Center (University of Southern California), have published a book on hereditary colorectal cancer entitled "Hereditary Colorectal Cancer. Genetic Basis and Clinical Implications".

The book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, genetic counselors, oncologists, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field from all over the world have contributed to this project, guaranteeing updated information, accuracy and discussion of topical issues.

 

Hereditary Colorectal Cancer. Genetic Basis and Clinical Implications. Editors: Laura Valle, Stephen B. Gruber, Gabriel Capellá. Springer International Publishing. DOI: 10.1007/978-3-319-74259-5. ISBN: 783319742595 (online); 9783319742588 (print).

 

Stem Cell Genetics for Biomedical Research: Past, Present, and Future


On the other hand, Dr. Raül Delgado-Morales, researcher and current scientific office manager at IDIBELL, has just released “Stem Cell Genetics for Biomedical Research: Past, Present, and Future”. The book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. 


In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a heoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

 

Stem Cell Genetics for Biomedical Research: Past, Present, and Future. Editor: Raul Delgado-Morales. Springer International Publishing. ISBN 978-3-319-90695-9