DRUG REPURPOSING FOR LUPUS NEPHRITIS THERAPY
- Compound X approved for use in humans.
- Able to be repurposed for lupus nephritis (LN) treatment without the associated toxicity by current standard treatment (steroids and immunosuppressive medication).
- Efficacy shown in a preclinical assay: oral administration in a LN animal model.
The principal goal of compound X therapy in lupus nephritis is to normalize renal function or, at least, to prevent the progressive loss of renal function. Therapy differs depending on the pathologic lesion. It might also be important for the treatment of other SLE manifestations, or even other autoimmune diseases.