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Breast cancer

imatge Central Grup Recerca

Scientific Team

Miguel Angel Pujana
Postdoctoral researchers
Francesca Mateo
Fernando Moreno, Sonia Pernas
Predoctoral researchers
Jordi Serra

Research lines

Predictive models of breast cancer risk associted to BRCA 1 & 2 and their modifiers



FA/BRCA pathway and its rol in breast cancer risk


Pre-clinical developement of novel therapies in endocrine resistant breast cancer

Gene expression and phenotipic characterization of ductal carcinoma in situ of the breast towards the delineation of invasion risk

Selected papers (2013)


Cufi S.,  Corominas-Faja B., Lopez-Bonet E.,  Bonavia R.,  Pernas S., Alvarez Lopez I., Dorca J.,  Martinez S.,  Batista Lopez N., Dominguez Fernandez S., Cuyas E., Visa J., Rodriguez-Gallego E., Quirantes-Pine R., Segura-Carretero A., Joven J.,Martin-Castillo B.,  Menendez J.A., Metten 10 Investigators

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin               

Oncotarget  2013 Sep;4(9):1484-95.


Quiles F.,  Fernandez-Rodriguez J.,  Mosca R.,  Feliubadalo  L., Tornero E.,  Brunet J.,  Blanco I., Capella G.,  Pujana M.A.,  Aloy P., Monteiro A., Lazaro C.

Functional and Structural Analysis of C-Terminal BRCA1 Missense Variants       

PLOS ONE. 2013 Apr. 8(4): e61302


Jolis, L.; Carabantes, F.; Pernas, S.; Cantos, B.; Lopez, A.; Torres, P.; Funes, C.; Caballero, D.; Benedit, P.; Salar, A.; Praxis Study Grp          

Incidence of chemotherapy-induced neutropenia and current practice of prophylaxis with granulocyte colony-stimulating factors in cancer patients in Spain: a prospective, observational study 

European Journal of Cancer Care.  2013 Jul;22(4):513-21


Couch, Fergus J.; Wang, Xianshu; McGuffog, Lesley; Lee, Andrew; Olswold, Curtis; Kuchenbaecker, Karoline B.; Soucy, Penny; Fredericksen, Zachary; Barrowdale, Daniel; Dennis, Joe; Gaudet, Mia M.; Dicks, Ed; Kosel, Matthew; Healey, Sue; Sinilnikova, Olga M.; Lee, Adam; Bacot, Francois; Vincent, Daniel; Hogervorst, Frans B. L.; Peock, Susan

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk       

PLoS Genetics. 2013;9(3):e1003212.


MohanP., Castellsague J., Jiang J.,  Allen K., Chen H.,  Nemirovsky O.,  Spyra M.,  Hu K.,  Kluwe L.,  Angel Pujana M., Villanueva A.,  Mautner V.F.,  Keats J.J., Dunn S.E.,; Lazaro C.,  Maxwell C.A.

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition              

Oncotarget. 2013 Jan;4(1):80-93.


Pellegrini P.,  Cordero A.,  Gallego M.I:, Dougall W.C., Munoz P.,  Pujana M.A.,Gonzalez-Suarez E.

Constitutive Activation of RANK Disrupts Mammary Cell Fate Leading to Tumorigenesis

Stem Cells  2013 Sep;31(9):1954-65

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Group leader

Miguel Angel Pujana
+34 932607463
© 2015 Institut d'Investigació Biomèdica de Bellvitge

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