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Cancer Virotherapy


Research lines

Cancer virotherapy with adenovirus


Cancer genic therapy with adenovirus


Selected papers (2014)

 

Rodriguez-Garcia A, Gimenez-Alejandre M, Rojas J, Moreno R, Bazan-Peregino M, Cascallo M, Alemany R.  Safety and efficacy of VCN-01, an oncolytic adenovirus combining fiber HSG-binding domain replacement with RGD and hyaluronidase expression. Clin Cancer Res. 2014 Nov 12. pii: clincanres.2213.2014.
 

 

Martinez-Quintanilla J, He D, Wakimoto H, Alemany R, Shah K. Encapsulated stem cells loaded with hyaluronidase-expressing oncolytic virus for brain tumor therapy. Mol Ther. 2014 Oct 29. doi: 10.1038/mt.2014.204


Dong W, van Ginkel JW, Au KY, Alemany R, Meulenberg JJ, van Beusechem VW.Hum  ORCA-010, a Novel Potency-Enhanced Oncolytic Adenovirus, Exerts Strong Antitumor Activity in Preclinical Models. Gene Ther. 2014 Oct;25(10):897-904. doi: 10.1089/hum.2013.229. Epub 2014 Sep 17.
 

 

Puig-Saus C, Rojas LA, Laborda E, Figueras A, Alba R, Fillat C, Alemany R. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy.Gene Ther.  Jun 19. doi: 10.1038. 2014.
 
 

José A, Rovira-Rigau M, Luna J, Giménez-Alejandre M, Vaquero E, de la Torre BG, Andreu D, Alemany R, Fillat C. A genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus. J Control Release.  Jul 15. pii: S0168-3659(14)00479-9. doi: 10.1016. 2014.


Lopez Gordo E, Podgorski II, Downes NL, Alemany R. Circumventing anti-vector immunity: Potential use of non-human adenoviral vectors. Hum Gene Ther. 2014. 25(4):285-300. 2014.

 
Majhen D, Calderon H, Chandra N, Fajardo CA, Rajan A, Alemany R, Custers J.  Adenovirus-based vaccines for fighting infectious diseases and cancer: progress in the field. Hum Gene Ther. 25(4):301-17. 2014.


Laborda E, Puig-Saus C, Rodriguez-García A, Moreno R, Cascalló M, Pastor J, Alemany R.A pRb-responsive, RGD-modified, and hyaluronidase-armed canine oncolytic adenovirus for application in veterinary oncology. Mol Ther. 22(5):986-98. 2014.


Puig-Saus C, Laborda E, Rodríguez-García A, Cascalló M, Moreno R, Alemany R. The combination of i-leader truncation and gemcitabine improves oncolytic adenovirus efficacy in an immunocompetent model. Cancer Gene Ther.  21(2):68-73. 2014.


Gil-Hoyos R, Miguel-Camacho J, Alemany R. Oncolytic adenovirus characterization: activity and immune responses. Methods Mol Biol. 1089:117-32. 2014.
 
 

imatge personal
 

Group leader

Ramon Alemany
Telephone  
+34 932607462
E-mail  
ralemany@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



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