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Chemoresistance and predective factors to tumor response and stromal microenvirontment


Research lines

Study of genetic and epigenetic mechanisms associated with the acquisition of resistance to chemotherapy in in several tumor types.

Study of tumour stroma as a modulator of tumor growth and response to chemotherapy.

Preclinical evaluation of new drugs with therapeutic potential.

Identification of interaction genes with established tumor pathways in C. elegans model.


Selected papers

Vidal A, Muñoz C, Guillén MJ, Moretó J,Puertas S, Martínez-Iniesta M, Figueras A,Padullés L, García-Rodriguez FJ, Berdiel-Acer M, Pujana MA, Salazar R, Gil-Martin M, Martí

L, Ponce J, Molleví DG, Capella G, Condom E, Viñals F, Huertas D, Cuevas C, Esteller M, Avilés P, Villanueva A.

Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer

CLINICAL CANCER RESEARCH

2012 Oct 1;18(19):5399-411

 

Aristizábal-Corrales D, Fontrodona L, Porta-de-la-Riva M, Guerra-Moreno A, Cerón J, Schwartz S Jr.
The 14-3-3 gene par-5 is required for germline development and DNA damage response in Caenorhabditis elegans.
Journal of Cell Science. 2012 Apr 1;125(Pt 7):1716-1726.

 

Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death.

Berdiel-Acer M, Bohem ME, López-Doriga A, Vidal A, Salazar R, Martínez-Iniesta M, Santos C, Sanjuan X, Villanueva A, Molleví DG.

Neoplasia. 2011 Oct;13(10):931-46

 

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis.

Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, Carneiro F, Esteller M.

Oncogene. 2011 Aug 29

 

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.

Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J, Vidal A, Aytes A, Puertas S, Ropero S, Kalluri R, Croce CM, Calin GA, Esteller M.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9.

imatge personal
 

Group leader

Alberto Villanueva
Telephone  
+34 932607343
E-mail  
avillanueva@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



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