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Chemoresistance and predective factors to tumor response and stromal microenvirontment



Research lines

Study of genetic and epigenetic mechanisms associated with the acquisition of resistance to chemotherapy in testicular, ovarian and colorectal tumours.

Study of tumour stroma as a modulator of tumor growth and response to chemotherapy.

Preclinical evaluation of new drugs with therapeutic potential in murine models.

Identification of interaction genes with established tumor pathways in C. elegans model.


Selected papers (2009)

Castillo-Avila W, Piulats JM, Garcia Del Muro X, Vidal A, Condom E, Casanovas O, Mora J, Germà JR, Capellà G, Villanueva A, Viñals F. Sunitinib Inhibits Tumor Growth and Synergizes with Cisplatin in Orthotopic Models of Cisplatin-Sensitive and Cisplatin-Resistant Human Testicular Germ Cell Tumors. Clinical Cancer Research. 2009;15(10):3384-95.

Dopeso H, Mateo-Lozano S, Mazzolini R, Rodrigues P, Lagares-Tena L, Ceron J, Romero J, Esteves M, Landolfi S, Hernández-Losa J, Castaño J, Wilson AJ, Ramon y Cajal S, Mariadason JM, Schwartz S Jr, Arango D. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res. 69: 7430-8 2009

Taniguchi H, Fernández AF, Setién F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M. Epigenetic Inactivation of the Circadian Clock Gene BMAL1 in Hematologic Malignancies. Cancer Research. 2009;69(21):8447-54.

Rodilla V, Villanueva A, Obrador-Hevia A, Robert-Moreno A, Fernández-Majada V, Grilli A, López-Bigas N, Bellora N, Albà MM, Torres F, Duñach M, Sanjuan X, Gonzalez S, Gridley T, Capella G, Bigas A, Espinosa L. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6315-20.

Melo SA, Ropero S, Moutinho C, Aaltonen L, Yamamoto H, Carneiro F, Oliveira C, Villanueva A, Capella G, Schwartz S Jr, Shiekhattar R and Esteller M. A TRBP mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 41: 365-70, 2009.

imatge personal
 

Group leader

Alberto Villanueva
Telephone  
+34 932607780
E-mail  
avillanueva@idibell.cat
 
© 2013 Institut d'Investigació Biomèdica de Bellvitge



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