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Ageing and Cancer

imatge Central Grup Recerca

Scientific Team

Researchers
Purificacion Muñoz,
Predoctoral researchers
Pilar Simón, Maria Victoria Da Silva
Technicians
Maria Urpi

Research lines

The research group are focused on the study of genetic and epigenetic changes in adult stem cells during aging and cancer, with the aim of understanding the higher incidence of cancer development during aging.


Selected papers (2009-2012)

 

P. Muñoz*, R. Blanco*, G. de Carcer, S. Schoeffner, R. Benetti, JM. Flores, M. Malumbres and MA Blasco. TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell Biol. : 29(6) 1608-25 2009

 

Schoeftner S, Blanco R, de Silanes IL, Muñoz P, Gómez-López G, Flores JM, Blasco MA. Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19393-8.

 

Martínez P, M. Thanasoula, P. Muñoz, C. Liao, A. Tejera, C. McNees, JM Flonres, O. Fernández-Capetillo, M. Tarsounas and MA Blasco. Increased telomere fragility and fusions from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes and Dev. 23(7): 2060. 2009

 

Huertas D, Sendra R and Muñoz P. Chromatin dynamics coupled to DNA repair. Epigenetics (4):1-12 (2009)       

 

Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M. Hernando-Momblona X, da Silva Diz V, Muñoz P, Clevers H, Sancho E, Mangues R and Batlle E. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell  8: 1-14  (2011)

 

da Silva-Diz V, Solé-Sánchez S, Valdés-Gutiérrez A, Urpi M, Riba-Artés D, Penin RM, Pacual G, González-Suárez E, Casanovas O, Viñals F, Paramio JM, Batlle E and Muñoz P. Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis. Oncogene (in press doi:10.1038/onc.2012.375)

imatge personal
 

Group leader

Purificacion Muñoz
Telephone  
+34 932607411
E-mail  
p.munoz@idibell.cat
 
© 2013 Institut d'Investigació Biomèdica de Bellvitge



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