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Epidemiology of bacterial infections. Investigation of the pathogenesis and molecular basis of antimicrobial resistance

Introduction
This research group includes different lines of research that include clinical and microbiological community-acquired and nosocomial infections caused by multiresistant bacteria, which cause significant morbidity and mortality. The study of risk factors and clinical features of hospital infections as well as the knowledge of the genotypes, virulence factors and antibiotic resistance mechanisms of bacterial pathogens are essential for controlling outbreaks of multiresistant bacteria. 
The genotypic characterization of strains causing community-acquired infections such as Streptococcus pneumoniae and S. pyogenes is very important because it allows to know the dominant clones in our geographic area and the coverage of new vaccines against these microorganisms. 
Infections caused by resistant Staphylococcus aureus (MRSA) are, by their frequency and clinical significance, a major issue in the field of nosocomial infections. The evaluation of active surveillance in the prevention of MRSA infections are a target with a major impact in terms of patient safety programs. 
The emergence of new antibiotic resistance genes and multidrug-resistant bacteria increased worldwide is of great concern. The spread of this resistance may be the result of clonal spread of strains or transfer of mobile genetic elements. This fact justifies the importance of screening and characterization of the mechanisms of antimicrobial resistance.

This research group includes different lines of research that include clinical and microbiological community-acquired and nosocomial infections caused by multiresistant bacteria, which cause significant morbidity and mortality. The study of risk factors and clinical features of hospital infections as well as the knowledge of the genotypes, virulence factors and antibiotic resistance mechanisms of bacterial pathogens are essential for controlling outbreaks of multiresistant bacteria. 


The genotypic characterization of strains causing community-acquired infections such as Streptococcus pneumoniae and S. pyogenes is very important because it allows to know the dominant clones in our geographic area and the coverage of new vaccines against these microorganisms. Infections caused by resistant Staphylococcus aureus (MRSA) are, by their frequency and clinical significance, a major issue in the field of nosocomial infections. The evaluation of active surveillance in the prevention of MRSA infections are a target with a major impact in terms of patient safety programs. 


The emergence of new antibiotic resistance genes and multidrug-resistant bacteria increased worldwide is of great concern. The spread of this resistance may be the result of clonal spread of strains or transfer of mobile genetic elements. This fact justifies the importance of screening and characterization of the mechanisms of antimicrobial resistance.


Research lines

Epidemiologia clínica i molecular de la malaltia pneumocòccica. 
Epidemiologia clínica i molecular de la bacterièmia/sepsis.
Epidemiologia clínica i molecular de les  infeccions causades per S. aureus resistent a la meticil·lina. 
Dinàmica de les poblacions microbianes en les exacerbacions de la malaltia pulmonar obstructiva crònica.
Caracterització molecular de les soques invasives de S. pyogenes.
Resistència als antimicrobians: caracterització fenotípica i estudi de les bases moleculars.
Noves  tècniques en el diagnòstic microbiològic.
Aplicació de la microscòpia de força atòmica per l’estudi del biofilm oral. 

. Clinical and molecular epidemiology of pneumococcal disease. 

 

. Clinical and molecular epidemiology of bacteremia / sepsis.

 

. Clinical and molecular epidemiology of infections caused by S. aureus resistant to methicillin. 

 

. Dynamics of microbial populations in exacerbations of chronic obstructive pulmonary disease. 

 

. Molecular characterization of invasive strains of S. pyogenes. 

 

. Antimicrobial resistance: phenotypic characterization and study of the molecular basis. 

 

. New techniques in microbiological diagnosis. 

 

. Application of atomic force microscopy to study the oral biofilm.

imatge personal
 

Group leader
Josefina Liñares
Telephone  
+34 932607930
E-mail  
jlinares@idibell.cat
 
© 2013 Institut d'Investigació Biomèdica de Bellvitge


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