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Research lines
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Identifying novel genes altered, at a genetic level, in cancer
Understanding how these abnormalities contribute to cancer development
Identifying molecular markers that determine sensitivity to novel cancer drugs.
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Selected papers (since 2011)
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The SWI/SNF genetic blockade: effects in cell differentiation, cancer and developmental diseases. Romero OA, Sanchez-Cespedes M. Oncogene (2013), in press.
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Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer. Pros E, Lantuejoul S, Bonastre E, Sanchez-Verde L, Castillo SD, Suarez-Gauthier A, Conde E, Cigudosa JC, Lopez-Rios F, Torres-Lanzas J, Castellvi J, Ramon y Cajal S, Brambilla E and Sanchez-Cespedes M. Int J Cancer (2013).
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UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status. Pallant P, Malapelle U, Berlingieri MT, Bellevicine C, Sepe R, Federico A, Rocco D, Galgani M, Sanchez-Cespedes M, Fusco A, Troncone G. Eur J Cancer. S0959-8049(12)00784-8 (2012).
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Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non small cell lung carcinoma through derepression of DUSP1phosphatase and inhibition of ERK. Maraver A, Fernández-Marcos PJ, Herranz D, Muñoz-Martin M, Gomez-Lopez G, Cañamero M, Mulero F, Megías D, Sanchez-Carbayo M, Shen J, Sanchez-Cespedes M, Palomero T, Ferrando A, Serrano M. Cancer Cell 22:222-34 (2012).
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SOX-family of genes in cancer development: biological relevance and opportunities for therapy. Castillo SD, Sanchez-Cespedes M Expert Op. Ther. Targets 16:903-19(2012)
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EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Bornachea O, Santos M, Martínez-Cruz AB, García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Maraver A, Ariza JM, Prosper F, Serrano M, Sánchez-Céspedes M and Paramio JM. Scientific Reports 2:434 (2012).
- The tumor suppressor BRG1 antagonizes Myc oncogenic activity and promotes cell differentiation in a nuclear receptor-dependent manner. Romero OA, Setien F, John S, Gimenez-Xavier P, Gomez-Lopez G, Pisano D, Condom E, Villanueva A, Hager GL, Sanchez-Cespedes M. EMBO Mol Med Mar 7. (2012).
- Identification of Novel Transcriptional Targets Links the SRY-HMG box gene SOX4 with the Development of the Small Cell Lung Cancer. Castillo SD, Matheu A, Mariani N, Carretero J, Lopez-Rios F, Lovell-Badge R, Sanchez-Cespedes M. Cancer Res. 2012;72:176-86.
- A DNA methylation fingerprint of 1628 human samples. Fernandez AF, Assenov Y, Martin-Subero JI, Balint B, Siebert R, Taniguchi H, Yamamoto H, Hidalgo M, Tan AC, Galm O, Ferrer I, Sanchez-Cespedes M, Villanueva A, Carmona J, Sanchez-Mut JV, Berdasco M, Moreno V, Capella G, Monk D, Ballestar E, Ropero S, Martinez R, Sanchez-Carbayo M, Prosper F, Agirre X, Fraga MF, Graña O, Perez-Jurado L, Mora J, Puig S, Prat J, Badimon L, Puca AA, Meltzer SJ, Lengauer T, Bridgewater J, Bock C, Esteller M. Genome Res. 2012;22:407-19
- Epigenetic disruption of cadherin-11 in human cancer metastasis. Carmona J, Villanueva A, Muñoz C, Penin MR, Gomà M, Piulats JM, Mesía R, Sanchez-Cespedes M, Manós M, Condom M, Eccles SA , Esteller M. J Path Feb 28 (2012).
- Composite anatomic-clinical-molecular prognostic model in non-small-cell lung cancer: a multicenter study of 512 patients. López-Encuentra A, López-Ríos F, Conde E, García-Luján R, Suárez-Gauthier A, Mañes N, Renedo G, Duque-Medina JL, García-Lagarto E, Rami-Porta R, González-Pont G, Astudillo-Pombo J, Maté-Sanz JL, Freixinet J, Romero-Saavedra T, Sánchez-Céspedes M, Gómez de la Camara A; on behalf of the bronchogenic carcinoma cooperative group of the spanish society of pneumology and thoracic surgery (GCCB-S). Eur Respir J;37:136-42 (2011).
- Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors. Rodriguez-Nieto S, Cañada A, Pros E, Pinto AI, Torres-Lanzas J, Lopez-Rios F, Sanchez-Verde L, Pisano DG, Sanchez-Cespedes M Hum Mut 32. E-1999-2017(2011).
- IASLC/ATS/ERS international multidisciplinary classification of lung adenocarcinomas. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DR, Powell CR, Riely GJ, Paul E. Van Schil PE, Austin JHM, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M et al. J. Thor Oncol. 6: 244-85 (2011).
- The role of LKB1 in lung cancer. Sanchez-Cespedes M. Fam Cancer April 23 (2011).
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