logo IDIBELL
Català  |   Castellano  |   English
Search
The InstituteResearchWhat's onPlatformsJob offers
 

News

boto imprimir
Date: 19/06/2014

Researchers discover that synaptic levels of clathrin protein are important for neuronal plasticity


Researchers of the group of cellular and molecular neurobiology of the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona, ​​led by researcher Artur Llobet, have shown that synaptic levels of the protein clathrin are a determinant factor for synaptic plasticity of neurons.

 

Chemical synapses and synaptic vesicular transmission cycle


Neurons transmit information in a specialized contact points called synapses. These structures consist of two elements: the presynaptic one, information donor, and postsynaptic, which receives the information. In the case of the presynaptic terminal, information is stored in vesicles containing neurotransmitters. When a stimulus arrives at the presynaptic terminal releases a vesicle by exocytosis. But to prevent the terminal to run out vesicles, immediately after exocytosis, occurs endocytosis. This coupling between exo and endocytosis defines what is known as vesicular synaptic vesicle cycle and is essential for neurons to release information correctly.

 

The vesicular cycle must adapt to constant changes in neuronal activity, and thus is a determinant of neuronal plasticity.

 

The dogma of the clathrin


Study investigators have sought to determine the role of clathrin in synaptic plasticity. "This protein is involved in all processes of endocytosis in all cells of the body and until now it was thought that it presents as abundant levels that it wouldn't pose a limiting factor" explained Artur Llobet.

 

"Our study," adds the researcher "questions this dogma because we found that in periods of intense neuronal stimulation, but within physiological levels, presynaptic levels of clathrin decrease reversibly. Ie levels clathrin are a dynamic property of the terminals".

 

"This is not surprising, what it is, is that a drop of only 20% are able to alter synaptic function. Specifically, this reduction reduces the number of vesicles that can be released, which has a direct action on exocytosis and therefore on the release of information. "

 

"In short," said Llobet "we showed that clathrin levels are a limiting factor for synaptic transmission, thus contributes to synaptic plasticity."

 

Article’s reference

 

Francisco J. López-Murcia, Stephen J. Royle and Artur Llobet. Presynaptic Clathrin Levels Are a Limiting Factor for Synaptic Transmission. The Journal of Neuroscience. Doi: 10.1523/JNEUOSCI.5081-13.2014

 





foto Researcher Artur Llobet
Researcher Artur Llobet

Share/Bookmark
 
© 2014 Institut d'Investigació Biomèdica de Bellvitge



Results by pageInitial date
Select date
TitleFinal date
Select date
Search


Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept



Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept


Cancell

Passwords doesn’t match
The password must have at least 6 characters
The new password can not contain special characters
User register

Name
Surname
Second Surname
E-mail
User
Password
Language


Accept


Cancell




You have not yet answered the Human Resources Strategy for Research survey. It will not take you more than five minutes. Your opinion is very important to improve IDIBELL.

Do you want to complete the survey now?

Yes

No




Further personal and contact information is needed to maintain IDIBELL databases.

Do you wish to fill the form now?

Yes

No