logo IDIBELL
Català  |   Castellano  |   English
Search
The InstituteResearchWhat's onPlatformsJoin us
 

News

boto imprimir
Date: 20/01/2016

Discovered a common genetic basis for all dementias


The increase in life expectancy in Western countries has brought to the surface, among other things, an increase in diagnosed cases of neurodegenerative diseases such as dementia would. We know very little about the cellular and molecular basis of these, and even fewer have treatments with a real impact on the course of the disease. The best known is Alzheimer's disease, but other relevant dementias in our area are also associated with Lewy bodies, that linked to Parkinson's disease and which could develop long-term Down syndrome. It is interesting to recognize that they all have similar characteristics under the microscope, with some overlap in the clinical symptoms, so you might think that there is a shared biological basis for all of them. Today, an article published in the Translational Psychiatry Journal (Nature group), Manel Esteller, director of the Epigenetics and Cancer Biology Program (PEBC) of the Bellvitge Institute for Biomedical Research (IDIBELL) and ICREA researcher professor of Genetics at the University of Barcelona, shows that all mentioned dementias possess a common group of chemically inactivated genes. This demonstrates the existence of a single initial trunk for the disease.

 

"We have analyzed the chemical marks that determine the activity of the genome, called the epigenome, of the gray matter from 75 patients with various dementias and have found that these people share an erroneous off or on of a common set of 20 genes." —Says Dr . Manel Esteller— "and what it is even more exciting is that some of them were also found by other groups independently, and this indicates that these genes could be truly involved in the development of Alzheimer's and dementia in general. Among these they include ankyrin-1, involved in contacts between cells and RHOM2 related to inflammatory processes.” —Dr Esteller explains, and concludes about his research— "Now, it will be important to begin studying whether these altered genes can be targets for drugs that are so necessary today for these increasing frequency diseases for which we have very few treatment options."

 

 

Article:

Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R, Schultz MD, Ansoleaga B, Garcia-Esparcia P, Pons-Espinal M, Martinez de Lagran M, Dopazo J, Rabano A, Avila J, Dierssen M, Lott I, Ferrer I, Ecker JR, Esteller M. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.

Translational Psychiatry, doi:10.1038/tp.2015.214, 2016.





foto Graphical representation of epigenomes obtained from the cerebral cortex (red) of healthy tissue and four patients with different types of dementia
Graphical representation of epigenomes obtained from the cerebral cortex (red) of healthy tissue and four patients with different types of dementia

Share/Bookmark
 
© 2016 Institut d'Investigació Biomèdica de Bellvitge



Results by pageInitial date
Select date
TitleFinal date
Select date
Search


Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept



Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept


Cancell

Passwords doesn’t match
The password must have at least 6 characters
The new password can not contain special characters
User register

Name
Surname
Second Surname
E-mail
User
Password
Language


Accept


Cancell




Encara no heu contestat l'enquesta de satisfacció sobre la píndola formativa sobre patents. No trigareu més de cinc minuts a fer-ho. La vostra opinió és molt important per millorar l’IDIBELL.

Voleu fer l’enquesta ara?

Yes

No




Further personal and contact information is needed to maintain IDIBELL databases.

Do you wish to fill the form now?

Yes

No





Please, remember to introduce your holiday’s planning in the application

Accept

Cancell